miRNA对新生儿缺氧缺血性脑损伤保护作用的研究进展

[中图分类号] R272.1 [文献标志码] A

ABSTRACT Hypoxic-ischemic brain damage（HIBD） is a leading cause of neonatal mortality and neurological dysfunction in the infants，and it remains a focal point of research in neonatology.MicroRNA （miRNA）is involved in neuraldevelopment，and its alterations is closelyassociated with the pathological progression of HIBD.However，there is a lack of effective integration of studies on the specific roles and mechanisms of miRNAs at diferent pathological stages of the disease.This review summarized the recent researches on miRNA in various stages of HIBD.During the hypoxic-ischemic phase，abnormal expression of certain hypoxia-related miRNAcan serve as novel biological diagnostic markers.In thecerebral edema phase，miRNA may maintain the integrity of the blood-brain barrier，alleviating neuronal swelling and structural changes.In the cerebral infarction phase，miRNA can inhibit the expression of apoptotic proteins，enhance the neuronal survival rates，reduce the infarct size，and improve neurological behavior. Further research into the mechanisms of miRNA in HBD will provide new insights for the development ofdiagnostic and therapeutic strategies for HIBD. KEYWORDsHypoxic-ischemic brain damage；Pathogenesis；MicroRNA；Newborn； Neuroinflammation

新生儿缺氧缺血性脑损伤（hypoxicischemicbraindamage，HIBD）是由于围生期室息引起未成熟脑组织的缺氧缺血性损害，甚至导致新生儿死亡或婴幼儿永久性神经系统功能障碍[1-2]。（剩余13329字）