利用离散选择试验测量慢性阻塞性肺疾病患者治疗与装置偏好的综述

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【中图分类号】 R563.9 【文献标识码】 ADOI： 10.12114/j.issn.1007-9572.2024.0585

【Abstract】BackgroundChronic obstructive pulmonary disease（COPD） is associated with a substantial disease burden.Theatributesofdiferent treatmentoptionsvary，whichcanafectpatientadherenceand，consequently，treatment outcomes.Discretechoice experiment（DCE）can identifythe keyfactors（atributes）influencing patientchoices，determine the most valuedatributes，andquantifythetrade-ofsbetweenatributes.DCEs have been widelyaplied in the healthcare field.ObjectiveToreviewandevaluatetheliteratureonDCEregarding treatmentanddevicepreferences among patients with COPD，with the aimof providing areference forconducting health preference-related research on COPD patients in China. MethodsLiterature utilizing DCEs to measure health preferences among patients with COPD was retrieved fromthe Web of Science Core Colection，PubMed，CNKI，Wanfang Data，CBM，and VIP Database.The PREFSchecklist was employed forqualityevaluation.The atributes inthe studiesandtheircorrsponding dimensions wereanalyzedanddiscused.Results Atotalof11studeswereincluded，allfromdevelopedcountries.Significantdiferenceswereobservedinthatributesdueto variations inresearchbjectivesandsubjects.Regarding treatment preferences，theproportions ofatributesrelated toeficacy， convenience，treatment burden，risk，and patient characteristics were 29% ， 29% ， 20% ， 11% ，and 11% ，respectively. Patients with COPDparticularlypreferredatributesrelatedtoefcacyandrisk dimensions，followedbytreatmentburdenand patientcharacteristics，withlessmphasisonconvenience.Fordevicepreferences，theproportionsofaributesrelatedtofeature design，device usage，and drug-related features were 36% ， 32% ，and 32% . COPD patients showed a strong preference for atributesrelatedtodevicedesignanddrugrelatedfeatures，folowedbydeviceuse.Theoverallqualityof theliteraturewas not relativelyhigh.ConclusionThereisadiscrepancybetweenthe frequencyofatributes included ineachdimensionand the dimensionspreferredbypatients，particularlywiththeconveniencedimensionbeing theleastpreferredintreatments.Todate， there is noapplicationofDCEsamong COPDpatientsin China.Inthefuture，morerelevantresearchshouldbecarriedoutbased on the actual situation in China to provide evidence for the improvement of COPD treatment.

【Key words】Pulmonary disease，chronic obstructive；Treatment preference；Device preference；Discrete choice experiment

慢性阻塞性肺疾病（chronic obstructive pulmonarydisease，COPD）是一种以持续气流受限为特征的常见慢性疾病，具有高患病率、高致残率和高病死率等特点，疾病负担沉重[1-2]，社会对该疾病的认知程度较低[3-4]。（剩余13002字）