抗纤益心方对扩张型心肌病病人IncRNA-mRNA-ceRNA调控网络的影响

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AbstractObjective：ToobservetheeffectoftheKangxianYixinFormulaontheteraryregulatorynetworkoflongnon-codingRNA （IncRNA）messegerRN（mRA）ompetivedogenousRNAceRNA）inpatientswitlaedardiomyopathyandtoploeits mechanismofactiononventrcularremodelingMethods：Basedontheprospectiveresearchmethodperipheralbloodsampleswere colectedfrom3OpaientswithdilatedcardiomyopathyintheWestemmedicinegroupandtheKangxianYixinFormulagroupafter treatmentfor6months.FivesamplesineachgroupwererandomlyselectedforceRNAchipanalysistoscrnfodiferentialInRNAand mRNAbeforeandaftertreatmenttoestablishtheceRNAregulatoryntwork.VennanalysisofiferentillyexpressdIncRNAbetwen groupswasconductedtoobtainteexpreionproflesoftecoactingIncRNAandtheIncRNAactingexclusivelyontheKangianYixin Formula.ThekeymRNAintheceRNAregulatorynetworkofthe KangxianYixinFomulagroupwerescreeedout，andtheceRNA regulatorynetworkswereestablishedrespectivlyResults：TheresultsofiferentalgenescreeningrevealedthattheWestemedicine groupidentied82diferentiallyexpresedInRNAand186diferentiallyexpressdRNA，wiletheKangianYixinFolagoup identied395dierentiallexpressedInsnd89diferetiallyexpresedmNVennanalyisrevealed25IcRNactioete and370lncRNAactingindependentlyontheKangxianYixinFormula.Utimately，fivekeyIncRNAwereinvolved（MSTRG.66929.5， NONHSA1874o83.1.1L-5：4）otetillht cardiomyopatpntiokeletolatiodsptidseloteinase TheKangxianYixinFormulamightimprovemyocardialfibrosisndinibitventricularremodelinginpatientswithdilatedcardomyopathy byregulatingtheceRNAnetworkmediatedbyMSTRG.66929.5，NONHSAT187420.1，ENST00382313.2，NONHSAT18721.1and Inc-FOXL2-5：4.

Keywordsdilatedcardiomyopathy;KangxianYiinForula;longnoncodingRNA;messengerRNA;competiveendogenousRNA

扩张型心肌病（dilatedcardiomyopathy，DCM）是无异常负荷条件下左室或双侧心室扩张，以心肌收缩能力降低为主要特征的排他性心肌病[1]。（剩余12893字）