沙库巴曲缬沙坦预防心房颤动射频消融术后晚期复发的系统评价

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AbstractObeieluaetienofiateurreofrialilfadiofrei Methods:ThedatabasesofPubMed,theCochraneLibrary,WebofScience,CNKl,WanFangData,andVIPDataweresearchedto colectanddooldralss)evaatingacbriaanitreamntoftriafibilioadiofrebatio TheretrievaltimewasfromtheestablishmentofthedatabasetoMay1024.Tworesearchersindependentlyscrenedteiterature, extractedthedataevaluatedtheriskofasinteincudedsudiesndperformedaMetaanalysisusingRevan5.3softwaresults: Atotalof10RCsinvolving929patientsereincudedTeresultsofMetaanalysisshowedthatcomparedwiththecontrolgroupthelate recurrencerate( OR=0.39 95%C1 0.30-0.51, P<0.000 01 ),leftatrialdiameter(LAD) MD=-0.25 95%C 1—0.32-—0.18, P<0.000 01 ),left atrial volume index(LAVI) (N 1D=-5.06 ,95%Cl—7.13--2.99, 1),leftventricularend-diastolicdiameter(LVEDD) MD=-0.16 95%Cl—0.25--0.07, P<0.000 01 ),N-terminal pro-brain natriuretic peptide(NT-proBNP)(MD —133.87, 95% Cl—157.61-—110.13, P<0.000 01),C-reactive protein(CRP) ND=-0.98 = 95%01-1.16-0.81 , P<0.000 01),interleukin-6(IL-6) (MD=-3.33 5 95%Cl—3.62--3.05, P<0.000 01 )decreased significantly in the experimental group,and left ventricular ejection fraction(LVEF)( MD= 4.71,95%Cl4.13-5.28, P<0.000 01)increased significantly.Conclusion:Current research indicates that sacubitri/valsartan is efective in preventinglatcudiofrblairlfiaiouetoliidantitdaiofddiu theabove conclusions need to be verified by more high-quality studies.

Keywordsatrialfibrilation;sacubitril/valsartan;radiofrequencyablation;late recurrence;systematicreview

心房颤动(atrialfibrillation,AF)是临床常见的心律失常类型。(剩余11049字)

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