中药活性成分靶向线粒体凋亡途径抑制食管癌的研究进展

打开文本图片集

中图分类号 R965；R75.1 文献标志码 A 文章编号 1001-0408（2025）10-128-06

DOI 10.609/j.issn.1001-0408.2025.10.2

Research progress on active components of traditional Chinese medicine inhibiting esophageal carcinoma by targeting mitochondrial apoptosis pathway

XIAO Junke1，MU Xiaoyan2，GUO Jiaojiao1，YANG Shangzhi1，CAO Xuewei1，GUO Zhizhong3（1. Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou ，China；2. Dept. of Oncology， Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China； 3. Dept. of Oncology，Henan Provincial Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou ，China）

ABSTRACT Esophageal carcinoma is a malignant disease with a high incidence rate and poor prognosis. The mitochondrial apoptosis pathway plays a pivotal role in the regulation of cell death and has become a focal point in current cancer therapeutics research. Various active components from traditional Chinese medicine（TCM）can target the mitochondrial apoptosis pathway to inhibit esophageal carcinoma，presenting as potential therapeutic agents for this disease. This paper summarizes relevant research on the inhibition of esophageal carcinoma by active components in TCM via targeting the mitochondrial apoptosis pathway. It has been found that flavonoids （casticin，icariin，luteolin，kaempferol，hesperetin，deguelin，etc.），terpenoids （oridonin，Jaridonin， artesunate，ethyl acetate fraction of pleurotus ferulatus triterpenoid，etc.），alkaloids （matrine，swainsonine，etc.），polyphenols （curcumin，epigallocatechin-3-gallate，corilagin，etc.），steroids（ α -hederin，polyphyllin Ⅵ ，etc.），phenols（optimized scorpion venom peptide CT-K3K7，gecko active polypeptide，etc.），volatile oils （cinnamaldehyde， ∝ -asarone，etc.） and other active components from TCM can target the intrinsic mitochondrial apoptosis pathway，induce apoptosis in esophageal carcinoma cells， and inhibit their proliferation，invasion and migration by regulating oxidative stress，blocking the cell cycle，regulating signaling pathways such as PI3K/Akt and MAPK.

KEYWORDS traditional Chinese medicine；active components；esophageal carcinoma；mitochondrial apoptosis；cell apoptosis； mechanism of action

2022年全球癌症数据分析显示，食管癌在所有癌症中的发病率居第9位，死亡率排第6位[1]。（剩余14139字）