NF- ∇⋅κB 信号通路在急性肺损伤中的作用及中药干预研究进展

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中图分类号 R85 文献标志码 A 文章编号 1001-0408（05）10-177-06

DOI 10.6039/j.issn.1001-0408.05.10.

Research progress on the role NF- κB signaling pathway in acute lung injury and TCM intervention

LIU Fuli1，BA Yuanming2（1. ； 2. Dept. ）

ABSTRACT Acute lung injury （ALI） is a common clinical inflammatory respiratory emergency with high morbidity and mortality，for which there is no effective and safe therapeutic drug. Nuclear factor- κB （NF- κB ），as a classic inflammatory signaling pathway，can interact with upstream and downstream regulatory factors such as Toll-like receptor 4（TLR4），mitogenactivated protein kinase （MAPK）， nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 （NLRP3），high mobility group box-1 protein 1 （HMGB1），to jointly affect ALI. This review summarizes the latest research findings in recent years regarding the treatment ALI through traditional medicine（TCM）interventions targeting NF- κB signaling pathways. It has been found that a variety TCM monomers （danshensu methyl ester，salidroside total glycosides， berberine，Codonopsis pilosula polysaccharides，ursolic acid，chrysophanol，and polyphenols from longan seed kernels，etc.）and compound formulas（Resolving-dampness and defeating-toxins formula，Jinyin qingre oral liquid，Xuebijing injection，Combined treatment lung and intestine，Huangqi baihe decoction，etc.） can modulate NF- κB signaling pathway，and can prevent and control ALI by inhibiting inflammation，improving oxidative stress，reducing apoptosis and modulating the intestinal flora in a multi-pathway manner.

KEYWORDS NF- σ⋅κB signaling pathway；acute lung injury；traditional medicine；mechanism

急性肺损伤（acute lung injury，ALI）是临床上常见的危及生命的肺部疾病之一，发病率及死亡率高[1]，对患者的生命健康造成了严重的威胁，且目前缺乏较为安全有效的药物治疗手段。（剩余14517字）