中药调控PI3K/Akt信号通路促进慢性创面愈合的研究进展

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中图分类号R965 文献标志码A 文章编号1001-0408（2025）08-1019-06

DOI 10.6039/j.issn.1001-0408.2025.08.23

Research progress of traditional Chinese medicine regulating PI3K/Akt signaling pathway to promote chronic wound healing

ZHU Zhenhui'，LI ，LENG ， CAI Tao'， SHEN Xuefa'， XIANG Xianxue'， HUANG Yongxin'（1.First Clinical Medical College， Guizhou University of Traditional Chinese Medicine， Guiyang 5500O2， China； 2.Dept.of Anorectal Surgery， the First Affliated Hospital of Guizhou University of Traditional Chinese Medicine， Guiyang 550001，China）

ABSTACTThepathogenesisofchronicwoundhealingiscomplexItisoftendifficulttohealduetoalongcourseof disease， diffcultyintreatmentanditseriouslyafectsthequalityoflifeinpatients.Theactiveingredients，coupletmedicinalsand compound formulasoftraditionalChinesemedicine（TCM）posssuniqueadvantages inthetreatmentofchronicwound healing. Thephosphatidylinositol3-kinase/proteinkinaseBPI3K/Akt）signalingpathwayisextremelycriticalinthetreatmentofchronic wound healingbyregulatingaseriesofbiologicalprocesesincludingcellapoptosisangiogenesisandinflammatoryesposes. ThisarticlereviewstherelevantresearchontheregulationofthePI3K/AktsignalingpathwaybyTCMtopromotechronicwound healing.Ithasbeenfoundthattheactiveingredientsof TCM（suchasgeniposide，astragaloside，andginsenosides，etc.）and comoun formulas（suchas Chonghe ointment，Huanglian ointment，Shirun shaoshang ointment，etc.）mainly reduce inflammatoryesponsespromoteangigenesisegulateellutophagy，andaccelerateoundhealingbyactivtingtheKAkt signalingpathway；atthesametime，there arealsoafewcouplet medicinals（suchasHuangqiHonghua）andcompound formulas （suchasXiangpiShengjiintment）thatexert antinflammatoryefectsbyinhibiting thissignalingpathway，topromote wound healing.

KEYWORDSTCM；active ingredients；couplet medicinals；compound formulas；chronic wound healing；PI3K/Akt signaling pathway； mechanism

创面愈合是一个复杂的生物学过程，涉及组织再生、修复与重建，旨在恢复受损组织的结构和功能。（剩余14004字）