中药调控NLRP3炎症小体改善心肌纤维化的研究进展

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中图分类号R965；R285 文献标志码A 文章编号 1001-0408（2025）08-1008-05

DOI 10.6039/j.issn.1001-0408.2025.08.21

Research progress on the improvement of myocardial fibrosis by traditional Chinese medicine through regulation of NLRP3 inflammasome

ZHANG Rui'，YAN Jingshun'，JIA Fuyun'，JIA Kexin'，LIU Chenyang'，LIU ，LI ，XU Qiang2（1. Graduate SchoolTianjin University of Traditional Chinese Medicine， Tianjin 3016l7， China；2.Dept.of Cardiology，the Second Afiliated Hospital of Tianjin University of Traditional Chinese Medicine， Tianjin 300150， China）

ABSTRACTMyocardialfibrosis（MF），characterizedbydecreased cardiacfunction and myocardial compliance，isa pathologicalprocessandaprogressionfactorinvariouscardiovasculardiseasesThenucleotide-bindingdomainleucine-richrepeat and pyrindomain-containingreceptor 3（NLRP3）inflammasome iscloselyrelated tothedevelopmentof MF.Recent studies have shownthattraditionalChinesemedicine（TCM）canregulatetheNRPinflammasometoaleviateMFBasedonthisthisarticle systematicallysummarizestheresearchprogressonthemechanismsbywhichTCMregulatestheNLRP3inflammasometo improve MF.It is foundthatactiveingredientsof TCM，suchasalkaloids（lycorine，vincristine，bufalin），saponins（astragaloside IV， diosgenin， ginsenoside ），terpenoids（celastrol，oridonin），and phenols（polydatin，curcumin，phloridzin） as well as TCM formulas（Zhachong shisanwei pillZhilong huoxuetongyucapsules，Luqiformula）caninhibit theactivationof the NLRP3 inflammasome， thereby suppressing the release of inflammatory factors such as interleukin- 1β and IL-18， reducing inflammatory damagetomyocardiatissuealeviatingexcessivedepositionoftheextracellulaatrixandthusexertingtheeecofiproving MF.

KEYWORDSactivecomponentof TCM；TCMformula； myocardialfibrosis；NLRP3inflammasome；mechanismof action

心肌纤维化（myocardialfibrosis，MF）是由中、重度冠状动脉粥样硬化性狭窄引起心肌纤维持续性和（或）反复加重的缺血缺氧所导致的心肌纤维组织增生。（剩余12705字）