膝痹膏皮肤用药安全性研究

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【摘 要】目的：对膝痹膏皮肤用药的安全性进行探讨。方法：以兔、豚鼠为模型进行动物实验，分别观察膝痹膏对家兔完整皮肤组和破损皮肤组的刺激反应，并进行豚鼠的皮肤过敏反应实验。结果：膝痹膏外用对兔的完整或破损皮肤均无刺激性。并且外用后未出现红肿、水肿等过敏现象。结论：膝痹膏临床皮肤用药安全、无毒。

【关键词】膝痹膏；皮肤刺激性实验；皮肤过敏性实验

【中图分类号】R285.5 【文献标志码】 A 【文章编号】1007-8517（2024）06-0025-03

DOI：10.3969/j.issn.1007-8517.2024.06.zgmzmjyyzz202406006

Safety Study of Shin Medication of Knee and ArthraLgia HerbaL Paste

GUO Tongtong1，2 LI Hongfei1 GUOXiying1 LIU Junchang2*

1.Children’s Hospital of Xinjiang Uygur Autonomous Region/Xinjiang Hospital of Beijing Children’s Hospital，Urumqi 830000，China;2.Xinjiang Medical University，Urumqi 830011，China

Abstract：Objective To discussthe safety of dermatologic using of Knee and ArthraLgia HerbaL Paste.Method As a model for animal experiment， rabbits， guinea pigs were observed Knee and ArthraLgia HerbaL Paste to the stimulation of rabbit skin and damaged skin group complete response， and guinea pig skin allergic reaction experiments. Results External application of Knee and ArthraLgia HerbaL Paste has no irritation on intact or damaged skin of rabbits.And after external use did not appear redness，oedema and other allergic phenomena.Conclusion Knee and ArthraLgia HerbaL Paste is safe and nontoxic in clinical medication.

Key words：Knee and ArthraLgia HerbaL Paste; irritation experiment; hypersensitivity experiment

膝痹膏处方源自《千金翼方·卷十六·诸膏第三》苍梧道士陈元膏，并且在《肘后救卒方》《千金要方》等书中均有记载，其中记载“患膝冷痛，摩之五日，亦愈”。（剩余2753字）