脓毒症相关性急性肾损伤的发病机制

摘要：脓毒症是由严重感染引起的炎症反应，可导致多器官损伤，包括急性肾损伤（AKI）。本文主要对脓毒症相关性急性肾损伤（S-AKI）的发病机制、危险性因素、诊断与治疗情况等进行综述，以期为临床上更好地诊治脓毒症，改善患者的预后提供指导。

关键词：脓毒症；急性肾损伤；炎症反应；发病机制

中图分类号：R631                                    文献标识码：A                                DOI：10.3969/j.issn.1006-1959.2024.05.033

文章编号：1006-1959（2024）05-0174-05

Pathogenesis of Sepsis-associated Acute Kidney Injury

HE Jiao-long1，NIE Fang-fei1，HU Long1，XU Yun-ling2

（1.Intensive Care Unit，the First Affiliated Hospital of Jishou University/People's Hospital of Xiangxi Tujia

and Miao Autonomous Prefecture，Jishou 416000，Hunan，China;

2.Institute of Basic Experiment，Tongde Hospital of Zhejiang Province/Zhejiang Province Institute of Traditional Chinese Medicine，Hangzhou 310007，Zhejiang，China）

Abstract：Sepsis is an inflammatory response caused by severe infection， which can lead to multiple organ damage， including acute kidney injury （ AKI ）. This article mainly reviews the pathogenesis， risk factors， diagnosis and treatment of sepsis-associated acute kidney injury （ S-AKI ）， in order to provide guidance for better clinical diagnosis and treatment of sepsis and improve the prognosis of patients.

Key words：Sepsis;Acute kidney injury;Inflammatory reaction;Pathogenesis

脓毒症（sepsis）是指病菌入侵血液循环后机体内免疫反应紊乱，引起全身炎症反应的综合征，以发热、心慌、气促和精神状态变化为主要症状，严重的脓毒血症常出现循环障碍和（或）器官功能障碍[1]。（剩余8099字）