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脓毒症相关性急性肾损伤的发病机制

摘要:脓毒症是由严重感染引起的炎症反应,可导致多器官损伤,包括急性肾损伤(AKI)。本文主要对脓毒症相关性急性肾损伤(S-AKI)的发病机制、危险性因素、诊断与治疗情况等进行综述,以期为临床上更好地诊治脓毒症,改善患者的预后提供指导。

关键词:脓毒症;急性肾损伤;炎症反应;发病机制

中图分类号:R631                                    文献标识码:A                                DOI:10.3969/j.issn.1006-1959.2024.05.033

文章编号:1006-1959(2024)05-0174-05

Pathogenesis of Sepsis-associated Acute Kidney Injury

HE Jiao-long1,NIE Fang-fei1,HU Long1,XU Yun-ling2

(1.Intensive Care Unit,the First Affiliated Hospital of Jishou University/People's Hospital of Xiangxi Tujia

and Miao Autonomous Prefecture,Jishou 416000,Hunan,China;

2.Institute of Basic Experiment,Tongde Hospital of Zhejiang Province/Zhejiang Province Institute of Traditional Chinese Medicine,Hangzhou 310007,Zhejiang,China)

Abstract:Sepsis is an inflammatory response caused by severe infection, which can lead to multiple organ damage, including acute kidney injury ( AKI ). This article mainly reviews the pathogenesis, risk factors, diagnosis and treatment of sepsis-associated acute kidney injury ( S-AKI ), in order to provide guidance for better clinical diagnosis and treatment of sepsis and improve the prognosis of patients.

Key words:Sepsis;Acute kidney injury;Inflammatory reaction;Pathogenesis

脓毒症(sepsis)是指病菌入侵血液循环后机体内免疫反应紊乱,引起全身炎症反应的综合征,以发热、心慌、气促和精神状态变化为主要症状,严重的脓毒血症常出现循环障碍和(或)器官功能障碍[1]。(剩余8099字)

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