冷沉淀凝血因子输注在消化道急性大出血合并凝血功能障碍患者中的应用研究

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Application of Cryoprecipitate Coagulation Factor Infusion in Patients with Acute Massive Gastrointestinal Hemorrhage Complicated with Coagulation Dysfunction/LI Saijing，LI Xiaofang，HE Ying，DENG Maolin，NING Yanyan.//Medical Innovationof China，2025，22（27）： 014-017

[Abstract] Objective： To investigate the application value of cryoprecipitate coagulation factor infusion in patients with acute massive gastrointestinal hemorrhage complicated with coagulation dysfunction.Method：A total of 106 patients with acute massve gastrointestinal hemorrhage complicated with coagulation dysfunction admited to Ji'an Central People's Hospital from April 2023toAugust 2O24 wereselectedand divided into control group （53 cases）and observation group（53 cases） according to random number table method.Both groups received conventional treatment.On this basis，the control group was treated with fresh frozen plasma infusion，while the observation group was combined with cryoprecipitate coagulation factor infusion on the basis of the control group.

The clinical efcacy，coagulationfunctionand inflammatoryresponseof the two groups were compared.Result：The total effective rate of the observation group was higher than that of the control group （ 'P<0.05 ） 2h after infusion， the PT，TT and APTT in both groups were shorter than those before infusion，andthe FIB in both groups were higher than those before infusion，however，the TT，PTandAPTTin theobservationgroup wereshorter than those in the control group，and the FIB washigher than that in the control group （ P <0.05）.24h after infusion，the levels of TNF- α ，IFN- γ and IL-6 in both groups were higher than those before infusion，while those in the observation group were lower than those in the control group （ ）.Conclusion：Cryoprecipitate coagulation factor infusion in the treatment of acute massive gastrointestinal hemorhagecomplicated with coagulation dysfunction canbeter improve coagulation function，inhibit inflammatory reaction and improve curative effect.

[Keywords] Acute massive gastrointestinal hemorrhage Coagulation dysfunction Fresh frozen plasma Cryoprecipitate coagulation factor

First-author'saddress： Department of Blood Transfusion，Ji'an Central People's Hospital， Ji'an 343000， China

doi：10.3969/j.issn.1674-4985.2025.27.004

消化道急性大出血会迅速降低血容量，促使血液内各种因子成分丢失，容易导致患者出现凝血功能障碍，病死率较高[。（剩余4928字）