中医药调控PI3K/Akt信号通路防治糖尿病认知障碍作用机制研究进展

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中图分类号：R255.4 文献标志码：A 文章编号：1007-2349（2025）07-0089-06

Research Progress on the Mechanism of Traditional Chinese Medicine Regulating the PI3K/Akt Signaling Pathway in the Prevention and Treatment of Diabetic Cognitive Impairment

ZHANG Zi-peng，LUO Yu- wen，AN Dong，LIANG Yong-lin，LIN Xin - jie， CHAI Chao（Gansu UniversityofTraditional ChineseMedicine，Lanzhou73oooo，China）

【AbstractDiabetes isan important risk factor for cognitive impairment.The mechanisms of the association betwendiabetesandcognitive impairment include insulin resistance，mitochondrial autophagy，inflammation，oxidative stress，etc.In recent years，a large number of studies have found thatthe phosphatidylinositol 3-kinase（PI3K）/protein kinase B（Akt）signaling pathway isan important targetfortheprevention and treatment of diabeticcognitivedysfunction（DCD）.Monomers and compound prescriptions of traditional Chinese medicine affect mammalian target of rapamycin（ mToR）， glycogen synthase kinase -3（GSK-3β） ， superoxide dismutase（ SOD）， postsynaptic density protein -95 （PSD -95），apoptosis inhibitor gene（Bcl -2）， etc. by regulating the PI3K/Akt signaling pathway，，thereby achievig metabolic regulation. It has multiple efects such as reducing insulin resistance，lowering inflammation and oxidative stressto prevent and treat DCD.It has the advantages of multi-target，all-round and smalladverse reactions，and is an important direction for new drug research and development.Basedon the P13K/Akt signaling pathway，this paper reviews its pathological mechanism in DCD and the research on traditional Chinese medicine intervention，with the aimof providing references for the prevention and treatment of DCD with traditional Chinese medicine and the development of clinical drugs.

【 Key words】Chinese Medicine; PI3K/Akt Signaling Pathway; DCD; Mechanism of Action; Research Progress

全球糖尿病患病率的上升是一个公共卫生问题， 统计显示，2021年全球糖尿病患病率约为 10.5% （5.366亿人），到2045年将上升到 12.2% （7.832亿）[1]。（剩余13554字）