基于网络药理学探究葛根治疗偏头痛的作用机制

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中图分类号：R747.2 文献标志码：A 文章编号：1007-2349（2025）07-0060-05

Exploration of the Mechanism of Kudzu Root in theTreatmentof Migraine Based on Network Pharmacology

LIU ΔYu-qi1 ， LIU Yun1 ，WANG Yu-jie1 ， TIAN Jin - yong² （1.Guizhou University of Traditional Chinese Medicine，Guiyang 55oo25，China; 2.Guizhou Provincial Peoples Hospital，Guiyang 55ooo2，China）

【Abstract】Objective：To explore the potential molecular mechanism of kudzu root in the treatment of migraine by using network pharmacology methods.Methods：Through database retrieval and prediction，the active components and potential targets of kudzu root were screened out and a drug -target-disease network wasconstructed. The gene ontology（G0） functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway enrichment analysis wereconducted to reveal the multi-target and multi-pathwaymechanism of kudzu rootin thetreatmentof migraine.Results：The core targets of kudzu root inthe treatment of migraine were TP53，SRC，AKT，MAPK3，and STAT3.The results of GO functional enrichment analysis mainly involved inflammatory responses.The KEGG pathway enrichment analysis revealed that kudzu root in the treatmentof migraine mainly involved neuroactive ligand-receptor interactions，nitrogen metabolism，etc.Conclusion： Kudzurot exerts its therapeutic efect onmigraine by intervening in neurotransmitter transmisson， inflammatory response， nitrogen metabolism regulation， etc.

【Key words】Kudzu Root； Migraine;Network Pharmacology

偏头痛是一种常见的慢性神经血管性疾病，其特征为反复发作的单侧或双侧搏动性头痛，常伴有恶心、呕吐、畏光、畏声等症状，严重影响患者的生活质量和工作效率[1]。（剩余6410字）