天青地白对2型糖尿病小鼠降血糖的研究

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Study on the Hypoglycemic Effect of Gnaphalium on Type 2 Diabetic Mice

CHEN Xia， ZHOU Meng -ting，YANG Hao （HunanMedicalCollege，Huaihua418ooO，China）

【Abstract】Objective：To explore the hypoglycemic efect of aqueous extract （TQ）of Gnaphaliumon type 2 diabetes mellitus（T2DM）. Methods：After 40KM male mice were adaptively raised for one week，1O were randomly selectedas thecontrol group.Theremaining mice wereraised with high sugarandhigh fatcombinedwith tail vein injection of streptozotocin （STZ）at 40mg/kg to establish the T2DM mouse model. The mice with successful modeling were randomly divided into a model group，a positive group and an experimental group.The experimental group was given the aqueous extract of Gnaphalium at 8g/kg ，the positive group was given metformin at 0.03g/kg ，and the control groupandthe model were given thesame volume of distilled water.After continuous intragastric administration for 4 weeks，the random blood glucose，triglycerides and total cholesterol ofthe mice in each group weredetected.The changes in the body weight，food intakeand water intake of the mice were recorded.Results：Compared with that of the normal group，the levelsof bloodglucose，triglyceridesand total cholesterol in the model group were significantly increased （ P<0.01 ），the body weight was significantly decreased （ P<0.01 ），and the food intake and water intake increased.Compared with theof the model group，the levelsof blood glucose and triglycerides in the experimental group were significantly decreased （ P<0.05 ， P<0.01 ），the weight increased，and the food intake and water intake decreased. Conclusion： This study found that Gnaphaliumcan reduce the blood glucose and triglyceride levels of type 2 diabetic mice and improve the symptoms of diabetes.

【Key Words】Gnaphalium； Herbal Medicine of Dong Nationality； Diabetes； Hypoglycemic ； Streptozotocin

近年来，由于生活水平的提高、饮食结构的改变以及日趋紧张的生活节奏方式等诸多因素的影响，2019年国际糖尿病联盟指出20岁～79岁的成年人中，患有糖尿病（Diabetesmellitus，DM）的人数已达4.63亿，我国这一数据也达到了1.164亿，已成为糖尿病"第一大国”[]。（剩余4438字）