肝硬化病人衰弱发生率及影响因素的Meta分析

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Incidence and influencing factors of frailty in patients with liver cirrhosis：a Meta-analysis

LU Yawei，ZHANG Hui，XU Jing，ZHONG Lei，XIANG Xiaoting

School of Nursing，Anhui Medical University，Anhui 230601 China

Corresponding AuthorZHANG Hui，E-mail：zhanghui310@126.com

AbstractObjective：To evaluate the incidence of frailty in patients with liver cirrhosis and its influencing factors.Methods：the Cochrane Library，Web of Science，PubMed，EMbase，CNKI，WanFang Database，VIP，and CBM were searched from the establishment of the database to June 2023. Literature selection，data extraction and quality evaluation were conducted independently by two researchers. Stata 14.0 and RevMan 5.3 software were used for statistical analysis.Results：A total of 19 articles were included，involving 7 437 patients.Meta-analysis showed that the prevalence of asthenia in cirrhotic patients was 27%.The major influencing factors for frailty included age （OR＝1.04，95%CI 1.02-1.07，P=0.002），etiologic alcoholic cirrhosis （OR＝1.47，95%CI 1.08-1.99，P=0.01），albumin （OR＝0.68，95%CI 0.51-0.92，P=0.01），MELD-Na score（OR＝1.08，95%CI 1.07-1.09，P＜0.001），ascites （OR＝2.14，95%CI 1.47-3.13，P＜0.001），hepatic encephalopathy（OR＝2.48，95%CI 1.95-3.15，P＜0.001）.Conclusions：Available evidence suggests that patients with cirrhosis have a higher incidence of frailty.Age，etiological alcoholic cirrhosis，MELD-Na score，ascites，hepatic encephalopathy，and albumin are the influencing factors for frailty in cirrhotic patients.Therefore，it is suggested that early identification and a series of intervention measures should be taken to delay or reverse the development of patients with debilitating cirrhosis.

Keywordscirrhosis;frailty;influencing factor；Meta-analysis;evidence-based nursing

摘要目的：系统评价肝硬化病人衰弱发生率及其影响因素。（剩余13272字）