维持性血液透析病人并发上消化道出血危险因素的Meta分析

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Risk factors for upper gastrointestinal bleeding in maintenance hemodialysis patients：a Meta-analysis

CHANG Yan，YU Xintao

Yangzhou Hospital of Traditional Chinese Medicine，Jiangsu 225000 China

Corresponding AuthorYU Xintao，E-mail：yxt158076381@qq.com

AbstractObjective：To conduct a Meta-analysis on the risk factors of upper gastrointestinal bleeding in maintenance hemodialysis patients.Methods：PubMed，EMbase，Web of Science，the Cochrane Library，CNKI，VIP and WanFang Database were searched.The search period was from the establishment of the database to July 2022.After literature screening，data extraction and quality evaluation was conducted by two researchers，statistical analysis was performed using RevMan 5.4 software.Results：A total of 10 articles were included.Meta-analysis results showed that the risk factors for upper gastrointestinal bleeding in maintenance hemodialysis patients were diabetes（OR=1.21，95％CI 1.06-1.38，P=0.005），smoking（OR=1.11，95％CI 1.03-1.20，P=0.004），age（OR=1.01，95％CI 1.00-1.02，P=0.02），COPD（OR=1.23，95％CI 1.04-1.45，P=0.02），CVD（OR=1.34，95％CI 1.16-1.55，P＜0.000 1），cirrhosis（OR=2.01，95％CI 1.67-2.43，P＜0.000 01），and warfarin（OR=5.57，95％CI 3.58-8.65，P＜0.000 01）.Conclusion：Existing evidence suggests that diabetes，age，smoking，COPD，CVD，cirrhosis and warfarin are independent risk factors for upper gastrointestinal bleeding in maintenance hemodialysis patients，and early intervention should be conducted to prevent upper gastrointestinal bleeding.

Keywordshemodialysis;upper gastrointestinal bleeding;risk factors;Meta-analysis;evidence-based nursing

摘要目的：对维持性血液透析病人并发上消化道出血的危险因素进行Meta分析。（剩余9908字）