DP化疗方案联合康莱特注射液对肺腺癌患者免疫功能及血管新生指标的影响

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摘 要 目的：探讨肺腺癌患者采用多西他赛+顺铂（DP）化疗方案联合康莱特注射液治疗的效果。方法：将92例肺腺癌患者随机分为对照组和观察组，各46例。对照组实施DP化疗，观察组在此基础上加用康莱特注射液治疗，均治疗2个周期，比较两组治疗效果、免疫功能、血管新生指标及不良反应。结果：治疗后，观察组疾病控制率，CD3+、CD4+比例和CD4+/CD8+比值高于对照组；CD8+比例，血管内皮生长因子A、碱性成纤维细胞生长因子水平和不良反应发生率低于对照组（P

关键词 肺腺癌 DP化疗方案 免疫功能 血管新生指标 不良反应

中图分类号：R286； R734.2 文献标志码：A 文章编号：1006-1533（2024）17-0036-04

引用本文 陈秀梅， 黄海福. DP化疗方案联合康莱特注射液对肺腺癌患者免疫功能及血管新生指标的影响[J]. 上海医药， 2024， 45（17）： 36-39.

Effects of DP chemotherapy regimen combined with Kanglaite injection on immune function and angiogenesis indexes in patients with lung adenocarcinoma

CHEN Xiumei， HUANG Haifu

[Department of Oncology， Shenzhen Hospital （Futian）， Guangzhou University of Traditional Chinese Medicine， Shenzhen 518000， China]

ABSTRACT Objective： To investigate the effect of docetaxel plus cisplatin （DP） chemotherapy regimen combined with Kanglaite injection in the treatment of patients with lung adenocarcinoma. Methods： Ninety-two patients with lung adenocarcinoma were randomly divided into a control group and an observation group with 46 cases each. The control group was treated with DP chemotherapy， while the observation group was additionally treated with Kanglaite injection， and all the treatments were lasted for two cycles. The treatment effect， immune function， angiogenesis indexes and incidence of adverse reactions were compared between the two groups. Results： After treatment， the disease control rate， CD3+， CD4+ levels， CD4+/CD8+ value were higher and the levels of CD8+， vascular endothelial growth factor A， basic fibroblast growth factor and the incidence of adverse reactions were lower in the observation group than the control group （P

KEY WORDS lung adenocarcinoma； DP chemotherapy regimen； immune function； neovascularization indices； adverse effects

肺腺癌为非小细胞癌，发病率较高，经胸部X线检查可见圆形肿块，肿块呈较慢生长，早期可有血性转移，淋巴结转移较晚，有研究指出，40%的肺部肿瘤为肺腺癌[1]。（剩余4571字）