注射用奥美拉唑联合紫珠粉对消化性溃疡并出血患者炎症因子表达的影响

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摘 要 目的：对注射用奥美拉唑联合紫珠粉治疗消化性溃疡并出血患者的临床疗效及炎症因子水平的表达进行探讨。方法：将92例消化性溃疡合并出血患者随机分为对照组和观察组各46例。对照组给以注射用奥美拉唑治疗，观察组给以注射用奥美拉唑联合紫珠粉治疗，比较两组临床疗效。结果：观察组总有效率、血管内皮生长因子和碱性成纤维细胞生长因子水平高于对照组；炎症因子水平和止血时间低于对照组（均P

关键词 奥美拉唑 紫珠粉 消化性溃疡 出血 炎症因子

中图分类号：R286； R573.2 文献标志码：B 文章编号：1006-1533（2022）07-0028-03

引用本文 高云， 司亚娟， 丁艳， 等. 注射用奥美拉唑联合紫珠粉对消化性溃疡并出血患者炎症因子表达的影响[J].上海医药， 2022， 43（7）： 28-30； 39.

Effect of omeprazole for injection combined with Zizhu powder on the expression of inflammatory factors in patients with peptic ulcer bleeding

GAO Yun， SI Yajuan， DING Yan， ZHANG Tian， MA Xing

（Department of Gastroenterology， the Seventh People’s Hospital of Zhengzhou， Zhengzhou 450000， China）

ABSTRACT Objective： To investigate the clinical efficacy of omeprazole for injection combined with Zizhu powder in the treatment of patients with peptic ulcer bleeding. Methods： Ninety-two patients with peptic ulcer bleeding were randomly divided into a control group and an observation group with 46 cases each. The control group was treated with omeprazole for injection while the observation group with omeprazole for injection combined with Zizhu powder， and the clinical efficacy was compared between the two groups. Results： The total effectiveness and the number of vascular permeability factors and basic fibroblast growth factors were higher， and the level of inflammatory factors and hemostasis time were lower in the observation group than the control group （all P

KEy wORDS omeprazole； Zizhu powder； peptic ulcer； bleeding； inflammatory factors

消化性溃疡是一种常见的胃肠道疾病，胃和十二指肠部位是其好发部位，幽门螺杆菌、不良饮食习惯、不规律作息等原因导致的胃酸分泌过多则是该病的主要诱因[1]。（剩余5474字）