同轴静电纺丝联合富血小板血浆敷料在慢性创面治疗中的应用前景

［摘要］富血小板血浆可促进慢性创面的愈合，但在临床应用过程中，传统的给药方式难以达到稳定持续的有效治疗浓度，治疗效果并不确定。本文对同轴静电纺丝联合富血小板血浆的相关研究进行综述，对同轴静电纺丝联合富血小板血浆的新型生物敷料治疗慢性创面的应用前景进行展望，以期为创面治疗提供新的思路。

［关键词］富血小板血浆；同轴静电纺丝；生物敷料；伤口愈合；综述

［中图分类号］R318［文献标志码］A［文章编号］2096-5532（2024）03-0467-03

doi：10.11712/jms.2096-5532.2024.60.108［开放科学（资源服务）标识码（OSID）］

［网络出版］https：//link.cnki.net/urlid/37.1517.R.20240730.1613.007;2024-07-3111：42：55

Application prospect of coaxial electrospinning combined with platelet-rich plasma dressing in the treatment of chronic woundSHAO Zhaoyin， ZHOU Ziyi， LENG Xiangfeng（Department of Burn and Plastic Surgery， The Affiliated Hospital of Qingdao University， Qingdao 266003， China）

［Abstract］Platelet-rich plasma can promote the healing of chronic wound， but in clinical application， the traditional administration method cannot achieve a stable and continuous effective treatment concentration， leading to an uncertain treatment outcome. This article reviews the research on coaxial electrospinning combined with platelet-rich plasma and explores the application prospect of the new biological dressing of coaxial electrospinning combined with platelet-rich plasma in the treatment of chronic wound， in order to provide new ideas for wound treatment.

［Key words］platelet-rich plasma; coaxial electrospinning; wound healing; biological dressings; review

创面愈合的过程包括止血、炎症、增殖以及组织重塑[1-2]，影响这一修复过程的因素众多，包括：内源性因素，如细胞、细胞因子、趋化因子、炎症因子、生长因子等；外源性因素，如营养状况、基础疾病、感染等。（剩余8370字）