左乙拉西坦联合奥卡西平在小儿癫痫治疗中的效果及不良反应分析

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【摘要】目的：探究癫痫患儿在治疗过程中应用左乙拉西坦与奥卡西平联合治疗的效果。方法：平均将76例癫痫患儿分为参照组与研究组，每组38例，比较两组治疗效果、异常放电控制情况、血清指标、智力水平以及不良反应发生情况。结果：治疗后，研究组治疗总有效率为97.37%，PIQ评分、VIQ评分及FIQ评分分别为（108.36±4.92）分、（102.65±4.64）分及（116.53±4.25）分，GFAP、S-100β、IgA及IgG水平分别为（2.53±0.42）ng/L、（0.40±0.09）μg/L、（0.24±0.09）g/L及（6.54±1.29）g/L，异常放电控制率及不良反应发生率分别为97.37%及5.26%，上述指标均优于参照组（P

【关键词】小儿癫痫；左乙拉西坦；奥卡西平；疗效；不良反应

Analysis of the effect and adverse reaction of levetiracetam combined with oxcarbazepine in the treatment of epilepsy in children

GUO Li， TANG Yan

Neijiang Health Vocational College， Neijiang， Sichuan 641100， China

【Abstract】Objective：To explore the effect of the combination therapy of leve tiracetam and oxcar bazepine in the treatment of children with epilepsy.Methods：An average of 76 epileptic children were divided into the reference group and the study group，with 38 cases in each group.The therapeutic effect，abnormal discharge control，serum indicators，intelligence level and adverse reactions of the two groups were compared.Results：After treatment，the total effective rate of treatment in the study group was 97.37%，PIQ score，VIQ scoreand FIQ score were （108.36±4.92）points，（102.65±4.64）points and（116.53±4.25）points，GFAP，S-100β，the IgA and IgG levels were（2.53±0.42） ng/L，（0.40±0.09）μg/L，（0.24±0.09） g/Land（6.54±1.29） g/L，the control rate of abnormal discharge and the incidence of adverse reactions were 97.37% and 5.26% respectively，which were better than those in the reference group（P

【Key？Words】Epilepsy in children； Levetiracetam； Oxcarbazepine； Efficacy； Adverse reactions

癫痫多发生于儿童时期，是一种具有复杂病因的脑功能障碍综合征，该病虽是慢性疾病，但会因反复发作而使患儿高热惊厥、全身强制性阵挛等症状愈发严重，严重影响了患儿的机体健康水平[1]。（剩余3710字）