线粒体途径凋亡及中医药应用在帕金森病中的研究进展

［摘要］帕金森病（PD）是一种神经系统退行性疾病，病程长、易复发。可导致肌力、姿势、步态及精神等异常，继而引发残疾。线粒体途径的细胞凋亡是导致PD发病的重要的可能因素，本文对线粒体途径凋亡与PD的关系、中医药对PD病机的探讨及其治疗作用作一综述，探索中医药对于PD的有效治疗手段。

［关键词］帕金森病；线粒体凋亡；中医药应用

doi：10.3969/j.issn.1674-7593.2023.04.021

ResearchProgressonMitochondrialPathwayApoptosisandApplicationsofTraditionalChineseMedicineinParkinson'sDisease

WangLei1，LiuDeshui2，ZhangYingbo2，ZhangXiaojie1，2，3**

1BasicMedicalCollege，HeilongjiangUniversityofChineseMedicine，Harbin150006;2DepartmentofPathology，QiqiharMedicalUniversity，Qiqihar161003;3HeilongjiangNursingCollege，Harbin150086

**Correspondingauthor：ZhangXiaojie，email：zxj4456@sina.com

［Abstract］Parkinson'sdisease（PD）isaprevalentneurodegenerativedisordercharacterizedbyachronicandrelapsingcourse.PDgivesrisetodiversefunctionalimpairments，encompassingabnormalitiesinmusclestrength，posture，gait，andmentalwell-being，oftenleadingtodisability.TheinvolvementofmitochondrialapoptosisholdssignificantrelevanceinthepathogenesisofPD.ThiscomprehensivearticleextensivelyexaminestheintricatemechanismsunderlyingPD-associatedmitochondrialpathwayapoptosis，whiledelvingintothepotentialtherapeuticstrategiesofferedbytraditionalChinesemedicine（TCM）forthemanagementofPD.ByexploringtheinterplaybetweenPDpathogenesisandTCM，thisstudyaimstoshedlightoneffectivetreatmentmodalitiesandbroadentheunderstandingofTCM'stherapeuticpotentialinPD.

［Keywords］Parkinson'sdisease;Mitochondrialapoptosis;TraditionalChinesemedicineapplication

帕金森病（Parkinson'sdisease，PD）是以中脑黑质致密部多巴胺能（Dopaminergic，DA）神经元的变性缺失为主要病理改变、以运动症状和非运动症状为主要表现的全球第二大神经系统退行性疾病，起病隐匿，进展缓慢［1-2］。（剩余7291字）