睾丸炎治疗的生理机制与调控网络研究进展

Research progress on the physiological mechanism and regulatory network of orchitis treatment

ABSTRACT：Orchitis is a common male genitourinary disorder that significantly impacts patients life quality.Current treatment strategies have certain limitations and side effects.Ongoing therapeutic strategies focus on the interactions and regulatory networks among pathways and factors involved in the progression of orchitis.The targeted pharmacological agents include inflammatory pathways （p38MAPK，NF-κB，PI3K/Akt），cytokines （TNF-α，IL-6），and the nitric oxide synthase （NOS） system.However，these studies are currently at the animal research stage，and further clinical investigations are necessary to validate their efficacy and safety before clinical use.This article reviews the preclinical animal studies on new treatment methods of orchitis from the aspects of autoimmunity and exogenous microorganism induction，including ketotifen furmarate，aspirin，L-NAME，activin A，cortisol，melatonin，methane，long non-coding RNA MEG3，Abaloparatide，recombinant type Ⅰ interferon，and so on.

KEY WORDS：orchitis; autoimmune disease; exogenous microorganism; molecular target; male infertility

摘要：睾丸炎严重影响患者生活质量，目前针对睾丸炎的治疗方法都存在一定的局限性和副作用。（剩余15444字）