身体质量指数与常见泌尿系肿瘤的因果关系：一项两样本孟德尔随机化研究

打开文本图片集

Causal relationship between constitutional index and urinary tumors：a two-sample Mendelian randomization study

WU Ming SHAO Jinkai CHAI Hongqiang PANG Lei

（1.The Fifth Clinical Medical College of Shanxi Medical University，Taiyuan  030012；2.Department of Urology，Shanxi Provincial Peoples Hospital，Taiyuan  030012，China）ABSTRACT：ObjectiveTo explore the causal relationship between the body mass index （BMI） and the risk of urinary tumors using two-sample Mendelian randomization.MethodsBMI data in IEU public database genome association and date of kidney cancer，prostate cancer，prostate cancer，bladder cancer were screened and analy through the inverse variance weighting method，MR-Egger regression analysis，weighted median analysis of two-sample mondel randomization method to evaluate the causal relationship between constitution index and urinary tumor.Finally，a sensitivity analysis was used to assess the stability and reliability of the results.ResultsGenetically-predicted BMI is positively related to the risk of kidney cancer （OR：1.442 5，95%CI：1.082 1-1.923 0，P=0.012 5），negatively related to the risk of prostate cancer （OR：0.992 6，95%CI：0.988 7-0.996 5，P=0.000 2），and had no causal relationship with the risk of bladder cancer （OR：1.000 3，95%CI：0.999 4-1.001 1，P=0526 9）.Sensitivity analysis and pleiotropy analyses showed that the results of this study were reliable and there was no heterogeneity.ConclusionGenetically-predicted BMI is a risk factor for renal cancer and a protective factor for prostate cancer.It is not associated with the risk of bladder cancer.This finding can provide reference for the potential risk of common urological tumors and the development of prevention strategies.

KEY WORDS：Mendelian randomization； body mass index；urinary tumors；causal inference；genome-wide association study；renal cancer；prostate cancer；bladder cancer摘要：目的采用两样本孟德尔随机化方法探究身体质量指数（BMI）与常见泌尿系肿瘤发病风险之间的因果关系。（剩余7714字）