基于CT值、胱抑素C和尿酸碱度的尿酸结石预测模型的构建与验证
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Development and evaluation of a prediction model for uric acid stones based on CT values，cystatin C and urine pH
HUANG Guoshuai LIU Haopeng WU Zeming
（1.Department of Urology，The First Affiliated Hospital of Soochow University，Suzhou 215006；2.Department of Urology，Suzhou High-Tech Zone Peoples Hospital，Suzhou 215006，China）ABSTRACT：ObjectiveTo identify the risk factors associated with uric acid stones，construct a nomogram model for predicting the occurrence of the disease，and evaluate its predictive performance.MethodsA retrospective analysis was conducted on the general and clinical data of 876 patients who underwent surgical treatment for stones at the Department of Urology，the First Affiliated Hospital of Soochow University，during Jan.2020 and Dec.2022.Based on the analysis results of stone composition，the patients were divided into the uric acid stone group （n=82） and non-uric acid stone group （n=794）.All patients were then randomly split into the training group （n=526） and validation group （n=350） in a ratio of 6∶4.The training group underwent LASSO regression，univariate，and multivariate logistic regression analyses to identify predictive factors associated with the occurrence of uric acid stones.Based on the factors，a nomogram model was constructed.The performance of the model was evaluated using the validation group data by comparing it with models from other research centers.ResultsLASSO regression，univariate，and multivariate logistic regression analyses revealed that cystatin C，urine pH，and stone CT values were predictive factors for uric acid stones.The area under the receiver operating characteristic curve （AUC） of the model was 0.968 for the training group and 0.956 for the validation group.Compared to other models，this model showed better predictive performance.The integrated discrimination improvement （IDI） and net reclassification index （NRI） in the training group were 0.420 0（95%CI：0.328 2-0.511 8），P<0.001，and 0.484 2（95%CI：0.321 3-0.647 2），P<0001，respectively.In the validation group，the IDI and NRI were 0.405 9 （95%CI：0.330 7-0.481 1），P<0.001，and 0365 3 （95%CI：0.211 6-0.519 0），P<0.001，respectively.ConclusionThe nomogram model based on cystatin C，urine pH，and stone CT values can predict the occurrence of uric acid stones more accurately than other models，and can serve as a clinical supportive tool for the treatment and prevention of stone recurrence.
KEY WORDS：uric acid stones； prediction model； risk factor； nomogram； cystatin C； urine pH； stone CT摘要：目的筛选尿酸结石发生的风险因素，构建预测尿酸结石发生的列线图模型并与其他模型进行对比，进一步评估其预测效能。（剩余8854字）