八水碳酸镧脱水热力学特性及四水碳酸镧超声制备新技术

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中图分类号：R917 文献标志码：A 文章编号：1673-3851（2025）07-0461-08

引用格式：，等．八水碳酸镧脱水热力学特性及四水碳酸镧超声制备新技术[J．浙江理工大学学报（自然科学），2025，53（4）：461-468.

Abstract： To develop a new technology for the preparation of lanthanum carbonate tetrahydrate （La2（CO3）3∙4H2O） ，thermal gravimetric analyzer and differential scanning calorimeter were employed to investigate the thermodynamic dehydration process of lanthanum carbonate octahydrate （La2（CO3）3∙8H2O） Furthermore，the activation energy for each dehydration stage was calculated using the Ozawa equation. Based on this， ultrasonic technology was introduced to facilitate the dehydration of La2（CO3）3∙8H2O to prepare La2 （CO3）3⋅4H2O ， and the phase， elemental composition， morphological structure， and phosphate binding capacity of La2（CO3）3∙4H2O were analyzed. The results indicated that La2（CO3）3∙8H2O sequentially lost 2， 2，and 4 crystal waters at 80°C ， 105°C ，and 350∘C ，respectively，and after losing 4 crystal waters， La2（CO3）3∙8H2O could transform into the more thermodynamically stable La2（CO3）3∙4H2O The La2（CO3）3∙4H2O produced by ultrasonic technology had high phase purity，contained no impurity elements，and exhibited a morphology of uniformly dispersed flakes. In addition，the phosphate binding rate of La2（CO3）3∙4H2O reached 98.27% within 27O minutes， demonstrating excellent phosphate binding efficiency.

The La2（CO3）3∙4H2O prepared using ultrasonic technology in this study，which exhibits excellent dispersibility and high phase purity， has significant potential in the treatment of hyperphosphatemia.

Key words： lanthanum carbonate octahydrate （La2（CO3）3∙8H2O） ; dehydration; activation energy; ultrasonic technology;lanthanum carbonate tetrahydrate （La2（CO3）3∙4H2O）

0 引言

碳酸镧在胃肠道环境释放的三价镧离子能有效结合体内的磷酸盐，形成难溶性磷酸镧复合物而随粪便排出，因而可作为降磷药物用于治疗高磷血症[1]。（剩余7690字）