Comamonas kerstersii细菌致病性的基因组分析(英文)

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Genomic Insights of Pathogenicity of Comamonas kerstersii

WANG Hui1，MING Desong2，WANG Mingxi1

（ 1. School of Medicine，Huaqiao University，Xiamen 361021，China；2. Quanzhou First Hospital Affiliated to Fujian Medical University，Quanzhou 362000，China ）

Abstract：To achieve better management of Comamonas kerstersii（C. kerstersii） infections，the aim was to understand its virulence and pathogenicity by analyzing the virulence factor genes （VFGs） in the genome of C. kerstersii 121606. The genome was sequenced previously， and the VFGs were predicted by BLAST searching through the VFDB database. The results showed that C. kerstersii contained a large number of VFGs，some of which were exemplified to correlate to the survival and growth in humans，and the pathogenicity of C. kerstersii in the gastrointestinal tract and lungs. Genomic analysis revealed that C. kerstersii might be an intracellular pathogen. The harbored VFGs were conducive to explaining its virulence and pathogenicity in gastrointestinal tract and lung infections reported in the literature or encountered in clinic. The data also provided ideal targets for novel antibiotic and vaccine development for the therapy of C. kerstersii infections.

Keywords：Comamonas kerstersii；virulence factor gene；pathogenicity；intracellular pathogen；gastrointestinal tract infection；lung infection

CLC Number：中图分类号：Q 939.48；R 378文献标志码：Document Code：A Article Number：文章编号：1000-5013（2024）03-0394-23

摘要：为了更好地管理Comamonas kerstersii （C. kerstersii）感染，通过分析C. kerstersii菌株121606基因组中的毒力因子基因（VFGs）来了解其毒力和致病性。（剩余64607字）