利格列汀片致口腔炎1例

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【中图分类号】 R977.1+5 【文献标识码】A

Stomatitis caused by linagliptin tablet： a case report

LI Jie LIU Xiaoyan HAN Yi

Department ofPharmacy， ZhangjiagangHospital ofTraditional Chinese Medicine，Zhangjiagang215600，JiangsuProvince，China

Correspondingauthor：HAN Yi，Email： hanxg2@sina.com

【Abstract】A 65-year-old male patient with type 2 diabetes developed who took linagliptin tablets for 6 months stomatitis liquid. After two weeks of treatment with triamcinolone oral ointment and Kangfuxin liquid，the symptoms did not improve. Clinical pharmacist consultation considered it to be caused by linagliptin tablets and advised the patient to discontinue linagliptin tablets， which was adopted by doctor. And，the patient was referred to the endocrinology department to adjust the glucose-lowering regimen.The oral lesions began to improve three days after discontinuation of the medication，and were completely healed at the third week of follow-up. The Naranjo's Assessment Scale was used to evaluate the association between linagliptin and stomatitis， with the result indicating ‘possibly related： Stomatitis is a rare adverse reaction of linagliptin. Conventional local use of corticosteroids and mouthwashes may be inefective，and timely discontinuation or reduction of the medication is necessary. This article may serve as a reference for clinical management of similar events.

【Keywords】Linagliptin; Ulcerative stomatitis; Adverse drug reactions

2型糖尿病（type2diabetes，T2DM）是全球性的公共卫生难题，其发病率及相关致死率逐年上升，对全球人民的健康福祉构成了严重威胁1]，应用降糖药物是控制高血糖的主要策略之一。（剩余7044字）