托伐普坦片引起严重急性肝损伤1例

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【中图分类号】R575；R972 【文献标识码】A

Severe acute liver injury induced by tolvaptan： a case report

WANGKexin，SHI Erxia，ZHOUZhongyan，HEXuan

DepartmentofPharmacy，TheFirstHospitalofHuhhot，HohhotOioo30，China Correspondingauthor：SHI Erxia，Email： shierxia20o0@163.com

【Abstract】A 66-year-old man was admitted with acute left heart failure and hyponatremia. On the first day of admission， 15mg tolvaptan tablets were given orally. On the second day of admisson，alanine transaminase and aspartate transaminase were significantly increased to 916.76U⋅L-1 and 1857.1U⋅L-1 ，respectively，which met the diagnostic criteria of severe acute liver injury. The drug was immediately stopped and hepatoprotective therapy was given，and on the 1Oth day of admission， the patient's liver function improved significantly， and on the 12th day of admission，the patient was discharged after his condition stabilised.The results of the correlation evaluation indicated that the development of acute liver injury in this patient is likely related to tolvaptan. This article discusses the mechanism， time of occurrence， population and treatment of tolvaptan-induced liver function injury， suggesting that clinical use of tolvaptan should be highly vigilant for acute liver function injury and routine monitoring of patients' liver function to ensure the safe use of the drug.

【Keywords】Tolvaptan tablets; Acute liver function injury; Adverse drug reactions

托伐普坦是一种选择性血管升压素V2受体拮抗剂，可特异性拮抗精氨酸升压素，主要用于治疗低钠血症和心力衰竭引起的体液潴留，可有效降低心力衰竭患者的前、后负荷[。（剩余8214字）