中国乙型肝炎疫苗免疫策略及接种进展

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摘要：乙型肝炎是全球重要的公共卫生问题。我国通过实施以乙型肝炎疫苗为核心的综合防控策略，在乙型肝炎防控方面取得了显著成效，但仍存在诸多问题和挑战。本文回顾了我国乙型肝炎免疫策略的发展历程，分析了不同人群的疫苗接种目标与进展，以及存在的问题及挑战，为进一步优化免疫策略和提升防控水平提供参考。

关键词：乙型肝炎疫苗；免疫；接种；疫苗，联合

基金项目：国家自然科学基金（11571272）

Strategies and advances in hepatitis B vaccination in China

TANG Lin1，2，XU Xia1，2，ZHOU Zemei1，2，WANG Xiaoqi1，2，LIJizhen1，2，YIN Zundong1，2，WANG Fuzhen1，2

1.National Immunization Program，Chinese Center for Disease Control and Prevention，Beijing 100050，China；2.National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases，Chinese Center for Disease Control and Prevention，Beijing 102206，China

Corresponding author：WANG Fuzhen，wangfz@chinacdc.cn（ORCID：0000-0002-6784-7711）

Abstract：Hepatitis B is a major global public health issue.Through the implementation of comprehensive prevention and control strategies centered on hepatitis B vaccination，China has achieved remarkable progress in hepatitis B prevention and control，while there are still many issues and challenges.This article reviews the development of hepatitis B vaccination strategies in China，analyzes the goal and advances in vaccination in different populations，and problems and challenges，in order to provide a reference for further optimizing vaccination strategies and improving the levels of prevention and control.

Key words：Hepatitis B Vaccines；Immunity；Vaccination；Vaccines，Combined

Research funding：National Natural Science Foundation of China（11571272）

乙型肝炎是全球范围内的重大公共卫生问题之一。（剩余18759字）