纳米药物递送系统在耐药病原菌防控中的研究进展

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中图分类号：S859 文献标志码：A 文章编号：1001-411X（2025）03-0287-14

Advances of nano-drug delivery systems in the prevention and control of drug-resistant pathogenic bacteria

ZHOU Yufeng， GAO Xin， DAI Wenqing， CUI Na， ZHANG Hongyan， LIAO Xiaoping （Collge of Veterinary Medicine， South China Agricultural University/National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria， Guangzhou 510642， China）

Abstract： The unregulated use of antimicrobial drugs and the evolution of bacterial selective pressure have led to an increasing number of drug-resistant pathogenic bacteria， which is a serious threat to livestock and poultry breding as wellas public health safety. With the development of nanotechnology，nano-drug delivery systems have shown a series of advantages in delivering antimicrobial drugs，such as improving the bioavailability of drugs，reducing the toxic side efects，and lowering the cost ofdrug use，which provide the new technologies and strategies for overcoming bacterial drug resistance. In this paper，we reviewed the progress of six nano-drug delivery system types of nanoemulsion， liposome， solid lipid nanoparticle， nano micelle， metal nanoparticle and nano gel in the prevention and control of drug-resistant pathogens， starting from the hazards of drug-resistant pathogens and the current status of their prevention and control in livestock and poultry. We expect to provide a reference for nano-drug delivery system application in the prevention and control of drug-resistant pathogen in livestock and poultry， and help the green and sustainable development of animal husbandry industry.

Key Words： Antimicrobial drug; Nano-drug delivery system; Bacterial infection; Drug resistance; Animal breeding; Sustainable development

抗生素耐药性（Anti-microbialresistance，AMR）是微生物在抗菌药物压力下不断自我进化，对原本敏感的抗菌药产生高度耐受的特性[1]。（剩余38700字）