缺氧诱导因子在胶质瘤细胞上皮-间质转化过程中对细胞迁移和侵袭影响的研究进展

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[中图分类号] R739.41 [文献标志码] A

Research progress in effects of hypoxia-inducible factors on cell migration and invasion during epithelial-mesenchymal transition in glioma cells

SHEN Zhongjun， ZHAO Yao，JIA Mingbo， ZHAO Liyan （1.Department of Blood Transfusion，Second Hospital，Jilin University，Changchun 13O041，China; 2. Department of Neuro-Oncology Surgery，First Hospital， Jilin University， Changchun l3O061，China）

ABSTRACTEpithelial-mesenchymal transition（EMT） is a critical process in the development of various cancers，including glioma. In glioma cels，the activation of hypoxia-inducible factors （HIFs）can influence the occurrence of EMT，promoting cell migration and invasion.This review aims to explore the role of HIF in the EMT process of glioma cells，focusing on its impact oncellmigration and invasion，including regulation of angiogenesis，metabolic reprogramming，glycolysis，and the immune system in the tumor microenvironment. Additionally，this review summarizes the role of HIF in EMT-related signaling pathways，such as Wnt/β -catenin （ β -catenin），Notch，and transforming growth factor- β （TGF- β ），and provides new insights and directions for further understanding the mechanisms of HIF in the EMT process of glioma cells.

KEYWORDS Hypoxia-inducible factor； Glioma； Epithelial-mesenchymal transition；Cell migration;Cell invasion

神经胶质瘤是中枢神经系统中最常见的肿瘤类型之一，近年来其发病率和死亡率呈上升趋势[1]。（剩余23770字）