脐带间充质干细胞在女性生殖系统疾病治疗中应用的研究进展

[中图分类号] R711.7 [文献标志码］A

ABSTRACTFemale reproductive system diseases， such as premature ovarian insuficiency（POI）， premature ovarian failure（POF），polycystic ovary syndrome（PCOS），intrauterine adhesions （IUA）， ulterus scar diverticulum，salpingitis，and tubal obstruction，may induce infertility，severely impacting patients’physical and mental health and quality of life. Curently，the umbilical cord mesenchymal stem cells （UCMSCs） have emerged as a research focus in gynecological and obstetric fields，demonstrating significant therapeutic potential for female reproductive system disorders. UCMSCs secrete various cytokines，activate relevant signaling pathways and key molecules，reduce inflammation mediators and oxidative stress，and prevent excessive cellular damage and apoptosis，thereby achieving therapeutic effects.In recent years，extensive studies have explored the therapeutic efects of UCMSCs on female reproductive system diseases.This article review the current in uitro and in uiuo research progress in

UCMSCs for treating female reproductive system diseases，aiming to provide the novel strategies and directions for future research and clinical applications. KEYWORDsUmbilical cord mesenchymal stem cells;；Female reproductive system diseases; Infertility；Tissue repair and regeneration；Regenerative medicine； Stem celltechnology

脐带间充质干细胞（umbilicalcordmesenchymalstem cells，UCMSCs）因其易于获取、伦理争议低和免疫原性低等特性，现已成为干细胞研究的热点[1]。（剩余21005字）