蛋白磷酸酶1结构和生物学功能及其与肿瘤发生发展关系的研究进展

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[中图分类号] R730.2 [文献标志码］A

ABSTRACTProtein phosphatase 1（PP1） is a widely expressed and highly conserved serine/threonine phosphatase in organisms. It regulates cellular signaling pathways by catalyzing the dephosphorylation of various proteins，thereby influencing biological processes such as cell proliferation，apoptosis，migration， and transcription.In vio，PPl does not exist as a free catalytic subunit but instead forms distinct PP1 holoenzymes by binding with at least one PPl-interacting protein （PIP）．

catalytic subunit and its specific regulatory proteins is central to PP1's function. Under normal conditions， PPl stably performs its dephosphorylation role in vivo； however，in tumors，PPl function is aberrantly regulated，leading to either increased or decreased PPl activity. PPl exerts a dual influence on tumorigenesis and progression，acting as a suppressor in some cancers while promoting oncogenesis in others.Based on domestic and international research findings on PP1，this review summarizes the structure and biological functions of PPl，as well as the impact of its various subunits on the development and progression of different cancers， including breast cancer， lung cancer， ovarian cancer， pancreatic adenocarcinoma（PAAD），liver cancer，endometrial cancer，esophageal cancer（EC），colorectal cancer， and glioblastoma （GBM）. This review aims to provide the insights for developing highly eficient and environmentally friendly anticancer drugs and therapeutic approaches targeting PP1 holoenzymes.

KEYWORDsProtein phosphatase 1； Serine-threonine phosphatase； Protein phosphatase 1 regulatoryproteins；Biological function；Dephosphorylation

蛋白质磷酸化是调节细胞功能的主要机制，主要调节位点在丝氨酸和苏氨酸残基上[]。（剩余21199字）