电免疫学在心房颤动发病机制和诊疗策略中的研究进展

【摘要】心房颤动（房颤）是临床上最常见的心律失常，严重影响患者生命健康及生活质量。目前房颤发生机制尚未完全阐明，研究表明免疫系统在房颤发生过程中被激活，参与心房重塑过程，并由此提出“电免疫学”的概念。现就免疫细胞电生理特性、免疫细胞与心肌细胞互作、免疫系统异常活动在房颤中的作用及机制进行系统综述。

【关键词】电免疫学；心房颤动；免疫系统；心房重塑；治疗

【DOI】10.16806/j.cnki.issn.1004-3934.2023.10.000

Research Progress in Electroimmunology in Atrial Fibrillation

YANG Na，SUN Huaxin，SHANG Luxiang，ZHOU Xianhui

（Department of Pacing and Electrophysiology，Department of Cardiac Electrophysiology and Remodeling，The first affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China）

【Abstract】Atrial fibrillation （AF） is the most common arrhythmia in clinic，which seriously affects the life health and quality of life of patients. At present，the mechanism of AF has not been fully elucidated. Studies have shown that the immune system is activated during the occurrence of AF and participate in the process of atrial remodeling，thus putting forward the concept of “Electroimmunology”. This article systematically reviews the electrophysiological properties of immune cells，the interaction between immune cells and cardiomyocytes，and the role and mechanism of abnormal activities of the immune system in AF.

【Key words】Electroimmunology；Atrial fibrillation；Immune system；Atrial remodeling；Treatment

心房颤动（房颤）是临床中最常见的心律失常，发病率和患病率呈逐年上升趋势[1]。（剩余14868字）