天麻对神经退行性疾病的作用及其机制研究进展

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本文引用：红）神经 10.3969/j 作用及其机究2进展J]，医学研究与 ·基础医学·

Abstract： Gastrodia elata，a precious traditional Chinese medicinal herb，has been widely utilized in the treatment of neurological disorders such as headaches，dizziness，insomnia，and epilepsy.Gastrodin and Gastrodia elata polysaccharides，two pivotal bioactive constituents derived from this herb，exhibit therapeutic effcacy in alleviating symptoms and improving outcomes in diverse neurological conditions and neural injuries. Neurodegenerative diseases，characterized by progressive degeneration and functional impairment of cells and tissues within the central nervous system，represent a significant global health burden. This article comprehensively reviews recent advances in understanding the mechanisms and therapeutic potential of gastrodin and Gastrodia elata polysaccharides across various neurodegenerative diseases. The aim is to provide a foundational reference for future clinical applications and mechanistic investigations of these bioactive components in the management of neurodegenerative pathologies.

Key Words： Gastrodin; Gastrodia elata polysaccharides ; neuroprotection ; neurodegenerative diseases ; Alzheimer disease；Parkinson disease

随着社会老龄化程度加剧，神经退行性疾病的发病率逐年攀升，流行病学调查指出，中国现有阿尔茨海默病（Alzheimerdisease，AD）患者占全国人口 19.8% ，帕金森病（Parkinsondis-ease，PD）患者占全球PD人口的 23%[1] ，神经退行性疾病严重影响了患者的生活质量和身心健康，给全球公共卫生系统带来了沉重的社会和经济负担。（剩余17310字）