不同临床分期慢性HBV感染患者血清CCL11水平及临床意义

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[关键词] 慢性乙型肝炎病毒感染;临床分期;嗜酸性粒细胞趋化因子11 中图分类号]R512.6+2 [文献标志码]A [DOI] 10.19767/j.cnki.32-1412.2025.05.003

AnalysisofCCL11expressiondifferencesinchronichepatitisBvirus andcorrelationwithliverfunctionindexes

QIANChen，QIANQiqi， CHEN Jia，ZHANG Bin， ZHANG Xian （Departmentof InfectiousDisease，NantongUniversityAffiliatedHospital，Jiangsu ）

[Abstract]Objective：To analyze the serum level of eosinophilicchemotactic protein11（CCL11） in patients with chronichepatitisBvirus （HBV）infectionatdiferentclinical stagesanditsclinical significance.Methods：Atotalof110 patients with chronic HBVinfection who were newlydiagnosedwere included.Thepatients were dividedinto5groups： 20 cases of HBeAg-positive chronic HBV infection，23cases of HBeAg-positivechronichepatitis B（CHB），27casesof HBeAg-negative chronic HBVinfection，24 casesof HBeAg-negative CHB，and16 casesof hepatis B liver cirrhosis. Enzyme-linked immunosorbent assay （ELISA）wasused to detect the serum levels of CCL11 of patients in each group. Pearsoncorrelationcoeffcient analysis wasconductedto investigate thecorrelation between serumCCL11 levelsand HBV DNAloadas wellas liver function indicators inpatients with chronic HBV infection.Results：Theserum CCL11level in the HBeAg-positive chronic HBV infection group was lower than that in the HBeAg-positive CHB group，the HBeAgnegative CHB group，and the hepatitis B liver cirrhosis group （all P<0.05 ）.The serum CCL11 level in the HBeAg-positive CHB group was lower than that in the HBeAg-negative CHB group and the hepatitis B liver cirhosis group （all P<0.0 5）. TheserumCCL11levelintheHBeAg-negativechronic HBV infection groupwaslowerthanthatintheHBeAg-negative

CHB group and the hepatitis B liver cirrhosis group（ P <0.05）.The Pearson correlation analysis showed that the serum CCL11levelinpatients withchronic HBVinfectionwaspositivelycorelatedwithalanineaminotransferase （ALT）（r=0.205， P =0.042）and aspartate aminotransferase （AST） （r=0.294， P =0.003）， but not correlated with HBV DNA load （r=0.141， P= 0.170）.Conclusion：Astheclinical stageof patients withchronic HBVinfectionprogresses，theserum CCL11level shows a gradually increasing trend.Theserum CCL11level iscorelatedwith liver transaminase，suggestingthatCCL11mayplay an important role in the process of liver inflammation and fibrosis.

[Key words]infectionof chronic hepatitis B virus; clinical stages；eosinophilicchemotactic protein11（CCL11）

慢性乙型肝炎病毒（hepatitisBvirus，HBV）感染是全球性公共卫生问题，据世界卫生组织统计，全球约有2.96亿HBV慢性感染者，每年死于肝硬化或肝细胞癌人数逐年增加I。（剩余4441字）