依达拉奉联合静脉溶栓对急性缺血性脑卒中患者神经功能及血液流变学指标的影响

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【Abstract】Objective To investigate the effcacy of edaravone combined with intravenous thrombolysis in thetreatment of acute ischemicstroke （AIS）patients.MethodsA total of ninety-fourAIS patientsadmitted to ourhospital from August 2022 to August 2O24 were randomly divided into two groups using a random number table.The control group（ n=47 ）received intravenousthrombolysiswith alteplase，while the observation group（ n= 47）wasalsotreatedwithedaravonefor14days.ThetreatmentefcacyNational Institutesof Health Stroke Scale （NIHSS）score，Barthel Index，hemorheological indicators，inflammatory factors，andadversereactionsbetween the twogroups were compared.ResultsThe treatment efect of the observation group was beter than that of the control group （ P <0.05）.NIHSS score and Barthel index between the two groupsbefore treatment had no significant difference （P>0.05） . Compared with the control group，the observation group had lower NIHSS score and higher Barthelindexafter treatment （ P <0.05）.Blood rheology indicatorsand inflammatory factor levels between the two groups before treatment had no significant difference （ P >0.05）.After treatment， the hemorheological indicators and inflammatory factor levels in the observation group were lower than those in the control group （P<0.05） . There was no significant difference in adverse reactions between the two groups （P>0.05） .ConclusionThe combination of edaravoneandintravenous thrombolysishasagood therapeuticefect onAIS patients，which is beneficial for improving hemorheological indicators，reducingneurologicaldamage，inhibiting inflammatoryreactions，restoring neurological function，improving dailyself-careability，and does not increasedrug adverse reactions.It is worthy of clinical promotion and use.

【Key words】Ischemic stroke;Pharmacotherapy， joint; Neurological function; Hemorheological indicators

急性缺血性脑卒中（AIS）是指脑部的供血动脉梗塞，导致局部脑组织发生缺血、缺氧性坏死，进而损伤患者神经功能，属于神经内科常见的急危重症，具有较高的发病率和病死率1。（剩余6103字）