重症肺炎患者中性粒细胞降钙素原对病情严重程度的预测及列线图分析

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Prediction of severityof illnessby nCD64 and PCT in patients with severe pneumoniaand analysis of columnchartsNiu Tairan.Department of Critical Care Medicine，Nanyang Hospital of Traditional Chinese Medicine，Henan47300o，China

【Abstract】ObjectiveTo study the value of neutrophil CD64 （nCD64）and procalcitonin （PCT） in predicting theseverityof diseaseinpatients with severepneumonia.MethodsNinety-six patientswith pneumonia received inour hospital from January 2O23to December 2O23wereretrospectivelyselectedand divided into mild andsevere groupsaccording to theseverity of the disease，and both groups were tested for the levels of nCD64 and PCT.Pearson's correlation analys was chosen toanalyze thecorrelation betweennCD64，PCTand the severity of thedisease，and the valueof nCD64，PCTand disease severity wasanalyzedbyplotting the column linegraph，calibration curveand the working characteristic curve of thesubjects（ROC）toanalyze thevalue of nCD64，PCTin predicting diseaseseverity.ResultsAtotal of 96patientswith pneumonia were included in this paper，among which 19 cases of severe pneumonia were included in the severe group，and the remaining 77 cases were included in the mild group.The levelsof nCD64 andPCTwere higher in theseveregroup than in the mild group （ P <0.05）.By constructing a column-line graph model for predicting the severity of pneumonia patients and drawing a calibration curve at thesame time，it was found thatthecalibration curve of the column-line graph model for predicting the severity of pneumonia patients was close to the ideal curve.nCD64and PCT had some predictive value in the severity of disease，especially the joint prediction corresponded to an AUC（95%CI）） value was 0.960 （O.904，1.O16），implying a higher value for joint prediction of disease severity （ P <0.05）. Conclusion The levels of nCD64 and PCT showed high expresion in patients with severe pneumonia，especially the value of thecombinationofthetwo in predicting theseverityof thedisease inpatientswith pneumonia ishigh，which can guide subsequent diagnosis and treatment.

【Key words】 Neutropenia; Pneumonia; Procalcitonin; Respiratory tract disease

重症肺炎作为临床较常见的呼吸系统疾病，其病因较复杂，使患者出现咳嗽、发热、呼吸困难等症状，同时具备病情发展速度快、病情严重、并发症较多等特点，若未及时采取有效干预措施，严重者可出现多器官功能衰竭，直接影响患者身心健康。（剩余5428字）