肿瘤坏死因子受体相关因子6血管生成素样蛋白8对短暂性脑缺血发作脑梗死发病风险的预测价值

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Predictive value of TRAF6 and ANGPTL8 in the risk of transient ischemic attack and cerebral infarction Zhang Tieshan*，WangDongmei， XingRuyue，ChenJun.*DeptartmentofEmergency，Afliated HospitalofYellow RiverUniversityofScienceand Technology，Zhengzhou45oooo，China

【Abstract】 ObjectiveTo analyze the predictive value of TRAF6 and ANGPTL8 for secondary cerebral infarction（CI） in transient ischemic attack （TIA）.MethodsAretrospective analysis was conducted onthegeneral andclinicaldataof 102TIApatients inour hospital from May2O22 to May 2024.Basedonwhetherthey had secondaryCI，they were clasifiedas CI group （22 cases）and non-CI group（8O cases），respectively.Therisk factors for secondaryCI in TIA patients were summarized，and the predictive value of TRAF6and ANGPTL8 for secondary CI in TIA patients wasanalyzed.ResultsTheage，body mass index （BMI），theproportionof hypertension，diabetes，hyperlipidemia，arterialstenosisrate，theproportionofcarotidplaque，the time fromonset tothefirstvisit，TIAduration，thenumberofTIAatacks，theriskassessmentscalefortransient ischemicattack （ABCD2）score，TRAF6，and ANGPTL8 in the CI group were higher than those in the non-CI group.BMI index， arterial stenosisrate，presence of carotidplaques，timefrom onset to first visit，durationof TIA，numberof TIA episodes，ABCD2 score，TRAF6，ANGPTL8 are risk factors for secondary CI in TIA.The combined detection of TRAF6 and ANGPTL8 showed higher sensitivity and specificity 83.8% ，78.3%） in predi-cting secondary CI in TIA compared to TRAF6 alone （81.1% ， 76.7% ）andANGPTL8alone 80.2% ，71.4 % ）， （AUC=0.861， 0.854， 0.853）. ConclusionThehigh expression of TRAF6and ANGPTL8 is a controllble risk factor for secondary CI in TIA. Combined detection of changes in TRAF6 and ANGPTL8 can achieve early prediction of CI risk.

【KeyWords】Ischemicatack，transient；Cerebral infarction;Risk factors；Receptor，tumor necrosis factor; Angiogenesis like protein 8

短暂性脑缺血发作（TIA）为临床常见脑血管病，通常是因脑、脊髓或视网膜局灶性缺血后引起，其病情严重程度不及脑梗死（CI）因此也被临床称为“小卒中”。（剩余7423字）