硼替佐米联合沙利度胺地塞米松治疗对多发性骨髓瘤患者炎症指标免疫功能的影响

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Efficacy bortezomib，thalidomide and dexamethasone on patientswith multiple myeloma Zhu Ruifeng， Zhou Shuiyang， Bao Weiying， Wang Hengshi， Fan Lu， Wang Liping， Wang Xiaoyan. ， ， ，2O1699，

【Abstract】ObjectiveThe eficacy bortezomib，thalidomide，and dexamethasone in treating patients withmultiple myeloma was investigated.MethodsA total 10O multiple myeloma patientsadmited to District Central in between August 2O2O and August 2023 wereenrolld assubjects for this study.These patients were randomlyassigned into two groups （5O each） by a random number table.The control group received thalidomideand dexamethasone，whereas theobservation group was administered bortezomib inaddition tothecontrol group'sregimen.Theclinical eficacy，inflammationmarkers，immune function，bone metabolism indicators，and adverse reactions between the two groups were compared.ResultsThe observation group demonstrateda higheroverall clinical efective rate compared tothe control group，with astatistically significant difference （P<0.05） .Post-treatment levels vascular endothelial growth factor （VEGF）， interleukin-6 （IL6），C-reactive protein （CRP）， interleukin-17 （IL-17），T lymphocyte subset CD 8+ ，and type I collagen C-terminal peptide（CTX-I） were lower in the observation group than those in the control group.Conversely，CD 4+ ，CD 3+ ， CD4+/CD8+ratios，osteocalcin （BGP），and alkaline phosphatase （ALP）levelswere higher，with all diferences being statistically significant（ P <0.05）.Adverse reactions between the two groups were comparable，with no statistically significant difference（ P >0.05）.ConclusionThecombineduse bortezomib with thalidomideand dexamethasoneinthe treatment multiplemyeloma patientsyieldssignificant therapeutic benefits，enhances immune function，reduces inflammatoryresponses，improvesbone metabolism，andexhibitsa high level safety.

【Key Words】Multiple myeloma;Dexamethasone;Bortezomib； Thalidomide； Inflammatory markers; Immu-nity

多发性骨髓瘤是一种恶性血液疾病，骨髓浆细胞恶性增殖是该病形成的主要原因，以骨痛、出血、肾功能不全、贫血等为临床表现，若控制不理想，会对机体内其他组织、器官造成严重损伤，大大降低了患者生存质量[12。（剩余5981字）