美洲大蠊的抗炎活性及作用机制研究进展

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关键词：美洲大；活性成分；抗炎活性；作用机制；研究进展中图分类号：R285.5 文献标志码：A 文章编号：1003-9783（2025）11-2006-07doi：10.19378/j.issn.1003-9783.2025.11.019

Research Progresson Anti-inflammatory Activityand Mechanismof Periplaneta americana

ZHANG Birong，SUI Shiyan，TAN You， ZHAO Min，LONG Jiangyu，YANG Lilian，XU Linjie，JIANG Rong（SchoolofPublic Health，DaliUniversity，Dali671ooo Yunnan，China）

Abstract：The traditional medicinal insect Periplanetaamericana has emergedasa focalpoint inanti-inflammatory research due to its rich pharmacological activities.Extractsandbioactive components from Periplanetaamericana， including peptides，aminoacids，polysaccharides，and coumarins，exhibit significant anti-inflammatory ffects.The mechanisms involve modulating immunecells，regulating nitric oxide（NO）and its synthase activity，mitigating mitochondrial dysfunction，restoring gut microbiota balance，and modulating inflammatorycytokines.Classical signaling pathways such as NF- κ B，MAPK，and JAK/STAT play pivotal roles in its anti-inflammatory actions.These findingsprovideatheoretical foundation for theclinical applicationof Periplanetaamericanaand thedevelopmentof novel anti-inflammatory therapeutics.

KeyWords：Periplaneta americana；active components；anti-inflammatory activity；mechanism of action；research progress

炎症是机体对损伤或感染的自我保护反应，旨在清除致病因子、修复受损组织。（剩余16105字）