甲硫氨酸限制在肿瘤治疗中的研究进展
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中图分类号：Q291 文献标志码：A 文章编号：1673-3851（2025）11-0854-10
引文格式：，．甲硫氨酸限制在肿瘤治疗中的研究进展[J]．浙江理工大学学报（自然科学），2025，536）：854-863.
Reference Format：GAOLianchao，XIA Chaoyi.Advances inmethionine restriction for cancer therapy[J].Journal of Zhejiang Sci-Tech University，2025，53（6） ：854-863.
Advances in methionine restriction for cancer therapy
GAO Lianchao ，XIA Chaoyi （Collge of Life Sciences and Medicine， Zhejiang Sci-Tech University， Hangzhou 3lool8，China）
Abstract： Methionine （Met），an essential amino acid，serves not only as a fundamental building block for protein biosynthesis but also as a critical node regulating cellular metabolic networks. Recent studies have revealed that various malignancies exhibit a distinct "methionine addiction" phenotype.This metabolic dependency arises from the aberrant demand and survival mechanisms of cancer cels for Met and its downstream metabolites. Consequently， methionine restriction （MR） has emerged as a promising therapeutic strategy in oncology. MR exerts its anti-tumor effects through multiple mechanisms： by disrupting S-adenosylmethionine （SAM）-dependent methylation reactions， impairing redox homeostasis， and suppressing polyamine synthesis.Notably，MR not only directly induces tumor cellcycle arrest and apoptosis but also remodels the tumor microenvironment and enhances anti-tumor immune responses. This review systematically summarizes the regulatory role of the Met metabolic pathway in tumor pathogenesis and the anti-tumor mechanisms of MR. It comprehensively reviews the latest research advances on the anti-tumor eficacy of MR in the treatment of various malignancies. Furthermore，it conducts an in-depth discussion on the clinical translation prospects and optimization strategies for MRbased therapies. The aim is to offer novel perspectives for developing metabolism-intervention-based precision cancer treatments.
Key words：cancer treatment；methionine；methionineaddiction；methionine restriction；Sadenosylmethionine
0 引言
癌症作为人类难治性疾病之一，其发病率和病死率居高不下，给人类健康带来了严峻挑战[]。（剩余25849字）
