锰与妊娠期并发症和出生结局的研究进展

打开文本图片集

[中图分类号]R173 [文献标识码]A [文章编号]1673—5293（2026）01—0011—07

Research progress on the associationsbetween manganese exposure and

pregnancy complicationsandbirthoutcomes

WU Yan1 ，WANG Susu² ，RAN Xiufang²，YAN Chonghuai1，2 （1.Shanghai Jiao Tong University School of Public Health，Shanghai 2OoO25，China;2.Ministry of Education-Shanghai KeyLaboratoryofChildren'sEnvironmental Health，XinhuaHospital Affiliatedto Shanghai Jiao TongUniversity School ofMedicine，Shanghai 2Ooo92，China）

[Abstract]Manganese（Mn），anesential trace element，plays acrucialrolein various physiological processesincluding osteogenesis，arbohydrateandlipidmetabolismantioxidantdefense，andneurotransmitersynthesisItsbiologicalefctsae characterizedbyadosedependentbiphasicregulatorypatern，which warrantsfurtherinvestigation.Withtheincreasinglevelsof environmentalpollutionpopulation-wideexposuretoMnhasrisensignificantly，particularlyafecting pregnantwomenandfetuses whoareonsideredhigh-riskgroupsduetoenhanced placentaltransportcapacityandincreasedphysiologicalrequirementsduring pregnancy.Thisreviewsummarizesrecentresearchadvanceson Mnexposureandmaternalandchildhealth（MCH）anddiscusses thecomplex associationsbetween Mnandpregnancycomplications aswellas fetalbirthoutcomes.Itaimstoprovidea comprehensive foundation and conceptual framework for future studies on the impact of Mn exposure on MCH.

[Key words]manganese;exposure;pregnancy complication;fetal birth outcome

锰是人体必需微量元素，在生长、发育和维持健康方面发挥重要作用，作为多种酶（如超氧化物歧化酶、精氨酸酶等）的重要构成要素参与营养素的代谢、骨形成、血糖调节、自由基防御系统，以及脑的氨清除和神经递质合成等过程，其摄入的主要途径是膳食和饮水[1]。（剩余16407字）