医药联合在弥漫大B细胞淋巴瘤合并急性肾功能衰竭患者中的治疗实践与分析

打开文本图片集

【中图分类号】R733.4【文献标识码】A DOI：10.12114/j.issn.1007-9572.2025.0061

【Abstract】BackgroundThe main treatment for difuse large B-cellymphoma is immunochemotherapy.However， thetransportofmostchemotherapydrugs inthebodyreliesontheparticipationof thekidneys.Forpatientswithdiffuselarge B-cellymphoma，thecoexistenceofsevererenalinsuficiencyundoubtedlyposesasignificantchallenge totreatment.During thetreatmentprocessdoctorsandpharmacistsnedtocloselycooperatetomaximiethetherapeuticbenefitsforpatintswhile ensuring theirsafety.ObjectiveToexplorethetreatmentservice model forpatientswithdifuselargeB-cellymphomalargeB-cellooadaliuecyJ]sealtic69（12）99.∘leddash Editorial Ofice of Chinese General Practice.This is an openaccessarticle under the CG BY-NC-ND4.0 license.

complicatedbyacuterenalfailure，soas toestablishefective preventiveand treatmentmeasures.MethodsTakingtheclinical data of a patientwithdiffuselargeB-cellymphoma complicatedwithsevererenal insufciencyhoreceived polatuzumabvedotin combinedwithchemotherapyasanexample.Exploretheetioogy，prognosticasessment，treatmentfeasibilityriskaessent and managementof tumorlysissyndrome，adjustmentof treatmentregimens，keypoints of pharmaceuticalcareanalysis and determinationofdialysis tming，etc.ResultsThepatient's treatmentprocesswasstable，andnoumorlysissyndromeocurrd. After2cyclesoftramt，testosfoompressieeldutealfrestivelylvddte lactatedehydrogenaselevel tendedtobenormal.ConclusionTherearesignificantindividual diferences among patients with difuselargeB-cellymphomacomplicatedbyrenalfailure.Theclinicaltreatmentregimensshouldbeindividualizedbasedon clearexaminationsandcomprehensive asessments.Doctors and pharmacistsshould strengthencommuncation to ensurethesafety and effectiveness of treatment.

【Key words】 Difse large B-cellymphoma; Acute renal failure; Treatmentadjustment; Dialysis; Tumorlysis syndrome

弥漫大B细胞淋巴瘤（DLBCL）是一类恶性程度高、侵袭性较强的肿瘤。（剩余16169字）