基于网络药理学对姜黄治疗痛风的作用机制研究

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Mechanism action turmeric on gout based on network pharmacology An Jingshuo.

【Abstract】Objective To predict the target turmeric's main active ingredients in the treatment gout， andtoexplore itsmulti-component，multi-target，multi-channel mechanism.MethodsThemain active components turmericwere screenedbythe TCM-PTD database，thepotential targets the above components were predicted bythe SwissTargetPrediction database，gout-related targets were obtained from the Human Genomes （GeneCards）databaseandthe CTD database.The target turmeric for gout was obtained，and theactive component-target network was constructed using Cytoscape 3.7.1 stware. The Gene Ontology （GO） and Kyoto Encyclopedia Genesand Genomes （KEGG） enrichment analysis were performed on the above targets using the Rlanguage package clusterPriler.Protein interaction network analysis target proteins was performed using BioGRID，InWeb_IM，andOmniPath databases.Visualizationand network topologyanalysiswereperformed by Cytoscapestware toobtain core targets.ResultsEight active ingredients，such as curcuminandbisabololwere obtained，which couldacton77targetsrelated togout.Theresults theGOenrichmentanalysisshowedthatthe above targets weresignificantly enriched inreactions involving metal ionsand oxidation.GO itemssuch asstress response：KEGG enrichment analysis showed that theabove targets weresignificantly enriched insignal pathways suchasFoxO signaling pathwayand interleukin（IL）-17 signaling pathway.ConclusionThe efect turmeric on goutreflects thecharacteristics multi-component，multi-targetandmulti-channel traditional Chinese medicine. It ishopedthatthisstudywillprovideascientificbasis forthescreeningactive ingredients inturmericand for further studies in pharmacology.

【Key words】 Network pharmacology;Turmeric; Gout；Target；Enrichment analysis

痛风是一种由体内嘌呤代谢紊乱或尿酸排泄障碍导致血尿酸水平升高，进而引发尿酸盐结晶沉积在关节、软组织及肾脏的炎症性疾病[1]。（剩余8085字）