与牙髓干细胞相关的骨组织工程研究进展

【摘要】 牙髓干细胞来自成人或儿童的牙髓组织，非常容易获得，且具有良好的增殖分化能力，被认为是在组织再生领域最有应用潜力的干细胞之一。牙髓干细胞在骨组织工程领域的研究由来已久，本文就牙髓干细胞的成骨分化潜能、相关的动物实验和临床试验、炎症牙髓干细胞和同种异体牙髓干细胞几个方面的研究进展作综述。

【关键词】 牙髓干细胞 组织工程 成骨分化 骨再生

Advances of Bone Tissue Engineering Related to Dental Pulp Stem Cells/WEI Daifu， WEI Xinrui， ZHAO Jian. //Medical Innovation of China， 2022， 19（14）： -175

[Abstract] With excellent multilineage differentiation potential and high proliferation rate， dental pulp stem cells are considered as one of the most promising stem cells in the field of tissue engineering， which can be easily obtained from dental pulp tissues of adults and children. Potential applications of dental pulp stem cells in bone tissue engineering have been studied for a long time， and this article mainly discusses it’s osteogenic differentiation potential， relevant animal experiments and clinical trials， as well as allogenic pulp stem cells and stem cells derived from inflammatory dental pulp tissues.

[Key words] Dental pulp stem cells Tissue engineering Osteogenic differentiation Bone regeneration

First-author’s address： School and Hospital of Stomatology， Laborartory of Periodontics， China Medical University， Shenyang 110002， China

doi：10.3969/j.issn.1674-4985.2022.14.042

组织工程是基于细胞或蛋白质与生物材料相结合来生成新组织的多学科领域，其中，骨组织再生一直以来都是学者努力探索的方向。（剩余11016字）