中药山茱萸治疗糖尿病肾病研究现状

摘要：山茱萸为常用中药材，补益肝肾，收涩固脱是其功效。山茱萸复方可以改善糖尿病肾病患者临床症状，降低尿蛋白排泄、改善肾功能等；其作用机制包括抑制肾组织白介素6（IL-6）等多种炎症因子分泌，抑制晚期糖基化终产物产生，减少肾小管上皮细胞中胆固醇积累，以及促进肾组织一氧化氮合成等。

关键词：山茱萸；糖尿病肾病；临床研究；作用机制

中图分类号：R692 文献标志码：A 文章编号：1007-2349（2023）12-0076-04

Research Status of Cornus officinalis in Treating Diabetic Nephropathy

LI Pu-lin1， YANG Chen-hui1， XIE Shao-feng1， HUANG Li-ji2

（1. The Third Clinical School of Nanjing University of Traditional Chinese Medicine/The Integrative Chinese andWestern Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine， Nanjing 210028， China; 2. The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine， Nanjing 210029， China）

【Abstract】Cornus officinalis is a commonly used Chinese herbal medicine and has the effect of tonifying liver and kidney. Cornus officinalis compound can improve the clinical symptoms of diabetic nephropathy patients， reduce urinary protein excretion， improve renal function and so on. Its mechanism of action includes inhibiting the secretion of various inflammatory factors such as interleukin-6 （IL-6） in renal tissue， inhibiting the production of advanced glycosylation end products， reducing the accumulation of cholesterol in renal tubular epithelial cells， and promoting the synthesis of nitric oxide in renal tissue.

【Key words】Cornus officinalis; Diabetic Nephropathy; Clinical Research; Action Mechanism

山茱萸屬于山茱萸科，补益肝肾，收涩固脱为其功效。（剩余5396字）