免疫细胞与慢性胰腺炎之间的因果关系：一项双向孟德尔随机化分析

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中图分类号： R657.5+1 文献标志码：ADOI：10.7652/jdyxb202503011

Causal relationship between immune cells and chronic pancreatitis： abidirectional Mendelian randomization analysis

WU Jiaoxing1，，CAO Ruiqi1，FENG Zhengyuan1，²，WU Shuai1²， DUAN Wanxing1'²，YANG Xue1，²，ZHOU Cancan1²，WU Zheng1，² （1.Department of Hepatobiliary Surgery，The First Affiliated Hospital of Xi'an Jiaotong University，Xi'an 7loo6l；2. Pancreatic Disease Center of Xi'an Jiaotong University，Xi'an 7lOo6l，China）

ABSTRACT：ObjectiveTo explore the casual relationship between immune cells and chronic pancreatitis （CP） using Mendelian randomization（MR）analysis.MethodsThe immune cellphenotypes and CP GWAS data used in this study were obtained from public databases，and73l immunecell phenotypes were included.The bidirectional MR analysis was used to explore the causal relationship between immune cels and CP，and various sensitivity analysis methods were used to verify the heterogeneity and level multiplicity of the results.ResultsThis study identified 33 immune cell phenotypes with acausalrelationship with CP，of which 18were inhibitoryfactors，and the rest were risk factors.Among the 18 inhibitory factors，CD25on CD4+ in the Treg cell group showed the most significant inhibitory effct.Among the 15 risk factors，CD8br AC inthe TBNKcellgroup，CD8bron TD CD8br in the mature T cell group，and CD39+ CD8br %T cell and CD28 on CD4+ in the Treg cell group showed statistical significance. The reverse MR results further confirmed the unidirectionality of the causal relationship.ConclusionOur study revealed the close relationship between immune celsand CP through MR method， highlighting the complex interaction pattern between the immune system and CP.

KEY WORDS： immune cell；chronic pancreatitis （CP）；Mendelian randomization （MR）analysis

慢性胰腺炎（chronicpancreatitis，CP）是一种进行性纤维化炎症性疾病，与多种危险因素有关[1]，主要表现为慢性疼痛、胰腺外分泌和内分泌功能不全[2]。（剩余10928字）