基于“六经病欲解时”理论应用乌梅丸治疗失眠

摘要 乌梅丸作为厥阴病主方，在“六经病欲解时”理论指导下，紧扣厥阴病“阴尽阳生、阴阳动荡、虚风内动、寒热错杂”病机，临床辨证应用于失眠治疗，尤其适用于丑至卯时（1：00—7：00）出现早醒、易醒，寒热错杂之失眠，可获良效，且可扩大应用于多种疾病治疗，但需注意用药指征、剂量、药物比例及禁忌等。

关键词 入睡和睡眠障碍；《伤寒论》；六经病欲解时；乌梅丸

Application of Wumei Pill in the Treatment of Insomnia Based on the

“Six Channels Disease at the Time of Resolution” TheoryLIU Ningzhou1，CAI Xia2，ZHAO Chengsi3，ZHANG Lixia4，GU Zhishan5

（1 Department of Preventive Treatment of Diseases，Shijingshan Hospital of Traditional Chinese Medicine，Beijing 100043，China;

2 Department of Traditional Chinese Medicine General Practice，Bajiao Community Health Service Center，Beijing 100043，

China; 3 Department of Internal Medicine，Eye Hospital of China Academy of Chinese Medical Sciences，Beijing 100043，

China; 4 Department of Ophthalmology，China Academy of Chinese Medical Sciences，Beijing 100070，

China; 5 Inheritance Studio of Gu Longsha Medical School，Jiangyin 214400，China）Abstract Wumei Pill，as the primary prescription for Jueyin disease，is guided by the “Six Channels Disease at the Time of Resolution” theory.This theory closely follows the pathogenesis of Jueyin disease，which includes “complete depletion of yin leading to the birth of yang，chaotic movement of yin and yang，internal movement of wind，and mixed cold and heat”. Clinically，it is applied to treat insomnia，especially insomnia with early awakening or easy awakening between the hours of Chou（1：00 to 3：00 AM） and Mao（5：00 to 7：00 AM），accompanied by mixed cold and heat symptoms.Wumei Pill has shown effective results and can be expanded for use in treating various diseases.However，careful attention should be paid to indications，dosage，medicinal ratios，and contraindications.

Keywords Sleep initiation and maintenance disorders; Shang Han Lun; Six Channels Disease at the Time of Resolution; Wumei Pill

中图分类号：R256.23；R222.2 文献标识码：B doi：10.3969/j.issn.2095-7130.2025.03.059

失眠属于中医学“不寐”范畴，《黄帝内经》称为“不得卧”“目不瞑”，临床以经常不能获得正常睡眠为特征，主要表现为睡眠时间、深度不足，轻者入睡困难，或睡而不酣，时睡时醒，或醒后不能再入睡，重则彻夜不眠，影响患者正常工作、生活、学习和健康［1］。（剩余5198字）