食管鳞状细胞癌侵袭、转移相关分子标志物的研究进展

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AbstractEsophageal squamous cellcarcinoma （ESCC） has a poor prognosis，and its invasion and metastasis are the maincauseof decreased patients‘qualityoflifeand survivalrate.The invasionand metastasis ofESCC involvemultiple mechanisms，including extracellular matrix degradation，epithelial-mesenchymal transition （EMT），andtumor angiogenesis， accompanied by molecularabnormalitiesatmultiple levels，such asnon-coding RNAs，EMT-related proteins，matrix metaloproteinases，vascularendothelial growth factor，exosomes，and circulating tumorcels.Predicting theriskof ESCC invasionandmetastasisandimplementingactiveinterventionsarecrucialforefectivetreatmentofESCCandimprovement of patients’qualityoflifeandsurvivalrate.Thisarticlereviewedtheresearch progressonmolecular markersrelated to invasion and metastasis of ESCC，aiming to provide insights for the early diagnosis and treatment of ESCC.

Key WordsEsophageal Squamous Cell Carcinoma;Invasion;Neoplasm Metastasis;Molecular Markers

食管癌是消化系统最常见的恶性肿瘤之一，2022年全球癌症统计报告显示，全球食管癌新发病例为51.1万，居所有肿瘤的第11位，死亡病例为44.5万，居所有肿瘤的第7位1。（剩余17237字）